CT55_CONPL
ID CT55_CONPL Reviewed; 68 AA.
AC P0C640; A8RCR5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=Conotoxin Pu5.5 {ECO:0000303|PubMed:17933431};
DE Flags: Precursor;
OS Conus pulicarius (Flea-bitten cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX NCBI_TaxID=93154;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=17933431; DOI=10.1016/j.peptides.2007.08.026;
RA Peng C., Wu X., Han Y., Yuan D., Chi C., Wang C.;
RT "Identification of six novel T-1 conotoxins from Conus pulicarius by
RT molecular cloning.";
RL Peptides 28:2116-2124(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is V (CC-CC).
CC -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC 'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC and AC P81755). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR EMBL; EF488467; ABS01339.1; -; mRNA.
DR AlphaFoldDB; P0C640; -.
DR ConoServer; 2797; Pu5.5 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR031565; T-conotoxin.
DR Pfam; PF16981; Chi-conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..49
FT /evidence="ECO:0000250"
FT /id="PRO_0000315451"
FT PEPTIDE 50..67
FT /note="Conotoxin Pu5.5"
FT /id="PRO_0000315452"
SQ SEQUENCE 68 AA; 7759 MW; 152C2DA2E680B01B CRC64;
MRCVPVFIIL LVLIASAPSV DARPQTKDDA LASFRDSIKR HLQTLLDARE CCPQSPPCCH
YYYYGSWK