CT55_HUMAN
ID CT55_HUMAN Reviewed; 264 AA.
AC Q8WUE5; Q9NWY8;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Cancer/testis antigen 55;
DE AltName: Full=Tumor antigen BJ-HCC-20;
GN Name=CT55; Synonyms=CXorf48;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Hepatoma;
RA Dong X.-Y., Chen W.-F.;
RT "Cloning and identification of genes which are differentially expressed in
RT hepatocellular carcinoma.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8WUE5; Q13515: BFSP2; NbExp=3; IntAct=EBI-6873363, EBI-10229433;
CC Q8WUE5; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-6873363, EBI-11519926;
CC Q8WUE5; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-6873363, EBI-8643161;
CC Q8WUE5; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-6873363, EBI-739879;
CC Q8WUE5; Q9NP86: CABP5; NbExp=3; IntAct=EBI-6873363, EBI-10311131;
CC Q8WUE5; Q96FN4: CPNE2; NbExp=5; IntAct=EBI-6873363, EBI-7097057;
CC Q8WUE5; P17661: DES; NbExp=6; IntAct=EBI-6873363, EBI-1055572;
CC Q8WUE5; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-6873363, EBI-6251402;
CC Q8WUE5; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-6873363, EBI-12013806;
CC Q8WUE5; P14136: GFAP; NbExp=3; IntAct=EBI-6873363, EBI-744302;
CC Q8WUE5; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-6873363, EBI-2805604;
CC Q8WUE5; Q6P597-3: KLC3; NbExp=3; IntAct=EBI-6873363, EBI-12076930;
CC Q8WUE5; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-6873363, EBI-739890;
CC Q8WUE5; Q16719-2: KYNU; NbExp=3; IntAct=EBI-6873363, EBI-12351611;
CC Q8WUE5; Q5VWZ2: LYPLAL1; NbExp=3; IntAct=EBI-6873363, EBI-6268634;
CC Q8WUE5; O95983-2: MBD3; NbExp=3; IntAct=EBI-6873363, EBI-11978579;
CC Q8WUE5; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-6873363, EBI-1104564;
CC Q8WUE5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-6873363, EBI-16439278;
CC Q8WUE5; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-6873363, EBI-10181968;
CC Q8WUE5; P23759-2: PAX7; NbExp=3; IntAct=EBI-6873363, EBI-12859446;
CC Q8WUE5; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-6873363, EBI-10232538;
CC Q8WUE5; P41219: PRPH; NbExp=3; IntAct=EBI-6873363, EBI-752074;
CC Q8WUE5; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-6873363, EBI-14067109;
CC Q8WUE5; Q92529: SHC3; NbExp=3; IntAct=EBI-6873363, EBI-79084;
CC Q8WUE5; Q96H20: SNF8; NbExp=3; IntAct=EBI-6873363, EBI-747719;
CC Q8WUE5; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-6873363, EBI-742688;
CC Q8WUE5; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-6873363, EBI-1105213;
CC Q8WUE5; Q08117-2: TLE5; NbExp=3; IntAct=EBI-6873363, EBI-11741437;
CC Q8WUE5; Q8N3L3: TXLNB; NbExp=4; IntAct=EBI-6873363, EBI-6116822;
CC Q8WUE5; P08670: VIM; NbExp=3; IntAct=EBI-6873363, EBI-353844;
CC Q8WUE5; Q13360-2: ZNF177; NbExp=3; IntAct=EBI-6873363, EBI-12272076;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WUE5-1; Sequence=Displayed;
CC Name=2; Synonyms=BJ-HCC-20B;
CC IsoId=Q8WUE5-2; Sequence=VSP_014465;
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DR EMBL; AY352211; AAQ90022.1; -; mRNA.
DR EMBL; AF520814; AAP47205.1; -; mRNA.
DR EMBL; AK000534; BAA91237.1; -; mRNA.
DR EMBL; AL670455; CAI41607.1; -; Genomic_DNA.
DR EMBL; AL670455; CAI41608.1; -; Genomic_DNA.
DR EMBL; BC020662; AAH20662.1; -; mRNA.
DR CCDS; CCDS14647.1; -. [Q8WUE5-2]
DR CCDS; CCDS35400.1; -. [Q8WUE5-1]
DR RefSeq; NP_001026875.1; NM_001031705.2. [Q8WUE5-1]
DR RefSeq; NP_060333.1; NM_017863.2. [Q8WUE5-2]
DR AlphaFoldDB; Q8WUE5; -.
DR SMR; Q8WUE5; -.
DR BioGRID; 120304; 51.
DR IntAct; Q8WUE5; 45.
DR MINT; Q8WUE5; -.
DR STRING; 9606.ENSP00000276241; -.
DR iPTMnet; Q8WUE5; -.
DR PhosphoSitePlus; Q8WUE5; -.
DR BioMuta; CT55; -.
DR DMDM; 68565599; -.
DR EPD; Q8WUE5; -.
DR jPOST; Q8WUE5; -.
DR MassIVE; Q8WUE5; -.
DR PaxDb; Q8WUE5; -.
DR PeptideAtlas; Q8WUE5; -.
DR PRIDE; Q8WUE5; -.
DR ProteomicsDB; 74663; -. [Q8WUE5-1]
DR ProteomicsDB; 74664; -. [Q8WUE5-2]
DR Antibodypedia; 30340; 25 antibodies from 10 providers.
DR DNASU; 54967; -.
DR Ensembl; ENST00000276241.11; ENSP00000276241.6; ENSG00000169551.13. [Q8WUE5-1]
DR Ensembl; ENST00000344129.2; ENSP00000343893.2; ENSG00000169551.13. [Q8WUE5-2]
DR GeneID; 54967; -.
DR KEGG; hsa:54967; -.
DR MANE-Select; ENST00000276241.11; ENSP00000276241.6; NM_001031705.3; NP_001026875.1.
DR UCSC; uc004eyk.2; human. [Q8WUE5-1]
DR CTD; 54967; -.
DR DisGeNET; 54967; -.
DR GeneCards; CT55; -.
DR HGNC; HGNC:26047; CT55.
DR HPA; ENSG00000169551; Tissue enriched (testis).
DR neXtProt; NX_Q8WUE5; -.
DR PharmGKB; PA134977669; -.
DR VEuPathDB; HostDB:ENSG00000169551; -.
DR eggNOG; KOG1804; Eukaryota.
DR GeneTree; ENSGT00940000163821; -.
DR HOGENOM; CLU_1165540_0_0_1; -.
DR InParanoid; Q8WUE5; -.
DR OMA; QFCYIWR; -.
DR OrthoDB; 1242774at2759; -.
DR PhylomeDB; Q8WUE5; -.
DR TreeFam; TF338795; -.
DR PathwayCommons; Q8WUE5; -.
DR SignaLink; Q8WUE5; -.
DR BioGRID-ORCS; 54967; 13 hits in 691 CRISPR screens.
DR GenomeRNAi; 54967; -.
DR Pharos; Q8WUE5; Tdark.
DR PRO; PR:Q8WUE5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8WUE5; protein.
DR Bgee; ENSG00000169551; Expressed in right testis and 45 other tissues.
DR Genevisible; Q8WUE5; HS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR025223; S1-like_RNA-bd_dom.
DR Pfam; PF14444; S1-like; 2.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..264
FT /note="Cancer/testis antigen 55"
FT /id="PRO_0000079739"
FT REGION 242..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 243..264
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_014465"
SQ SEQUENCE 264 AA; 29052 MW; 9EB884C8FD9C823B CRC64;
MLRLLRLALA FYGRTADPAE RQGPQQQGLP QGDTQLTTVQ GVVTSFCGDY GMIDESIYFS
SDVVTGNVPL KVGQKVNVVV EEDKPHYGLR AIKVDVVPRH LYGAGPSDSG TRVLIGCVTS
INEDNIYISN SIYFSIAIVS EDFVPYKGDL LEVEYSTEPG ISNIKATSVK PIRCIHTEEV
CITSVHGRNG VIDYTIFFTL DSVKLPDGYV PQVDDIVNVV MVESIQFCFI WRAISITPVH
KSSSGFQDDG GLGRPKRERR SQSI
