ID   CT56_CONPL              Reviewed;          60 AA.
AC   P0C641; A8RCS0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Conotoxin Pu5.6 {ECO:0000303|PubMed:17933431};
DE   Flags: Precursor;
OS   Conus pulicarius (Flea-bitten cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=93154;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17933431; DOI=10.1016/j.peptides.2007.08.026;
RA   Peng C., Wu X., Han Y., Yuan D., Chi C., Wang C.;
RT   "Identification of six novel T-1 conotoxins from Conus pulicarius by
RT   molecular cloning.";
RL   Peptides 28:2116-2124(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC).
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; EF488468; ABS01340.1; -; mRNA.
DR   AlphaFoldDB; P0C641; -.
DR   ConoServer; 2799; Pu5.6 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..47
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315453"
FT   PEPTIDE         48..59
FT                   /note="Conotoxin Pu5.6"
FT                   /id="PRO_0000315454"
SQ   SEQUENCE   60 AA;  6839 MW;  53B1D5E2446F0E2F CRC64;
     MRCVPVFVIL LLLIASAASI DAQQKTKDDA PLTSLNDNAL QQHWNKRCCP RKIWCCMIPR