ID   CT56_CONSP              Reviewed;          62 AA.
AC   C0KYC5; C0KYC7;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Conotoxin Sr5.6 {ECO:0000303|PubMed:19447151};
DE   AltName: Full=Sr5.8 {ECO:0000303|PubMed:19447151};
DE   Flags: Precursor;
OS   Conus spurius (Alphabet cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lindaconus.
OX   NCBI_TaxID=192919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SR5.6 AND SR5.8).
RC   TISSUE=Venom duct;
RX   PubMed=19447151; DOI=10.1016/j.peptides.2009.05.003;
RA   Zamora-Bustillos R., Aguilar M.B., Falcon A., Heimer de la Cotera E.P.;
RT   "Identification, by RT-PCR, of four novel T-1-superfamily conotoxins from
RT   the vermivorous snail Conus spurius from the Gulf of Mexico.";
RL   Peptides 30:1396-1404(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19447151}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Sr5.6;
CC         IsoId=C0KYC5-1; Sequence=Displayed;
CC       Name=Sr5.8;
CC         IsoId=C0KYC5-2; Sequence=VSP_038849;
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19447151}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; FJ646607; ACN22845.1; -; mRNA.
DR   EMBL; FJ646609; ACN22847.1; -; mRNA.
DR   AlphaFoldDB; C0KYC5; -.
DR   ConoServer; 3696; Sr5.6 precursor.
DR   ConoServer; 3695; Sr5.8 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..44
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392719"
FT   PEPTIDE         47..61
FT                   /note="Conotoxin Sr5.6"
FT                   /id="PRO_0000392720"
FT   MOD_RES         61
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         22..36
FT                   /note="Missing (in isoform Sr5.8)"
FT                   /evidence="ECO:0000303|PubMed:19447151"
FT                   /id="VSP_038849"
SQ   SEQUENCE   62 AA;  6853 MW;  A7DCF7A21F419E97 CRC64;
     MRCLPVFVIL LLLIASASSV DAQLKTKDDV PLTSVHDNAK GTQHRRIMAG CCPRFYQCCY
     PG