CT58_CONLT
ID CT58_CONLT Reviewed; 62 AA.
AC Q1A3Q5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Conotoxin Lt5.8 {ECO:0000303|PubMed:16908117};
DE AltName: Full=Lt5h {ECO:0000312|EMBL:ABC70195.1};
DE Flags: Precursor;
OS Conus litteratus (Lettered cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX NCBI_TaxID=89445;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA Dong M., Chen S., Xu A.;
RT "Diversity and evolution of conotoxins based on gene expression profiling
RT of Conus litteratus.";
RL Genomics 88:809-819(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16908117}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:16908117}.
CC -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC 'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC and AC P81755). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR EMBL; DQ345359; ABC70195.1; -; mRNA.
DR AlphaFoldDB; Q1A3Q5; -.
DR ConoServer; 1146; Lt5h precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR031565; T-conotoxin.
DR Pfam; PF16981; Chi-conotoxin; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..47
FT /evidence="ECO:0000250"
FT /id="PRO_0000315435"
FT PEPTIDE 50..61
FT /note="Conotoxin Lt5.8"
FT /id="PRO_0000315436"
FT MOD_RES 50
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 61
FT /note="Glutamine amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 62 AA; 7023 MW; AA535928175A62F4 CRC64;
MLCLPVFIIL LLLVSPAATM PVDLEILKAP TKESRKDFEM RIELLRSKRQ CCRPANMSCC
QG