ID   CT593_CONTE             Reviewed;          63 AA.
AC   Q3YEH2; Q9BPG9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Conotoxin TeAr193 {ECO:0000303|PubMed:16765485, ECO:0000312|EMBL:AAZ85406.1};
DE   AltName: Full=Conotoxin TxMRCL-03 {ECO:0000312|EMBL:AAG60387.1};
DE   Flags: Precursor;
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16765485; DOI=10.1016/j.peptides.2006.05.002;
RA   Luo S., Zhangsun D., Zhang B., Chen X., Feng J.;
RT   "Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus
RT   textile.";
RL   Peptides 27:2640-2646(2006).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=22709442; DOI=10.1021/pr300312h;
RA   Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA   Yates J.R. III, Bern M.;
RT   "Constrained de novo sequencing of conotoxins.";
RL   J. Proteome Res. 11:4191-4200(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22709442}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:11158371}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; AF214959; AAG60387.1; -; mRNA.
DR   EMBL; DQ141141; AAZ85406.1; -; mRNA.
DR   AlphaFoldDB; Q3YEH2; -.
DR   ConoServer; 1678; Conorphin-T precursor.
DR   ConoServer; 646; Conorphin-T precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Disulfide bond; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..48
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000274098"
FT   PEPTIDE         51..62
FT                   /note="Conotoxin TeAr193"
FT                   /evidence="ECO:0000269|PubMed:22709442"
FT                   /id="PRO_0000274099"
FT   CONFLICT        62..63
FT                   /note="TK -> PS (in Ref. 1; AAG60387)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   63 AA;  7137 MW;  9C2B0CFB2F12EF0A CRC64;
     MRCLPVFVIL LLLIASAPSV DAQPKTKDDI PQASFLDNAK RYLQVLESKR NCCRRQICCG
     RTK