ID   CT5A_CONMR              Reviewed;          59 AA.
AC   P69764;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Conotoxin mr5a {ECO:0000303|PubMed:15733570};
DE   Flags: Precursor;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Walker C., Shetty R., Olivera B.M., Hooper D., Jacobsen R., Steele D.,
RA   Jones R.M.;
RT   "Tau-conotoxin peptides.";
RL   Patent number US6630573, 07-OCT-2003.
RN   [2]
RP   PROTEIN SEQUENCE OF 50-59, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=15733570; DOI=10.1016/j.toxicon.2004.12.008;
RA   Han Y.-H., Wang Q., Jiang H., Miao X.-W., Chen J.-S., Chi C.-W.;
RT   "Sequence diversity of T-superfamily conotoxins from Conus marmoreus.";
RL   Toxicon 45:481-487(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15733570}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:15733570}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1107.99; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15733570};
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; BD270189; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   AlphaFoldDB; P69764; -.
DR   ConoServer; 1714; MrVA precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..48
FT                   /evidence="ECO:0000305|PubMed:15733570"
FT                   /id="PRO_0000035027"
FT   PEPTIDE         50..59
FT                   /note="Conotoxin mr5a"
FT                   /evidence="ECO:0000269|PubMed:15733570"
FT                   /id="PRO_0000035028"
SQ   SEQUENCE   59 AA;  6626 MW;  C3A33DBB221F8316 CRC64;
     MRCLPVFVIL LLLIASAPSV DARPKTKDDM PLASFHDNAK RILQILQDRN ACCIVRQCC