ID   CT5A_CONVC              Reviewed;          54 AA.
AC   P69765;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Conotoxin vc5a {ECO:0000303|PubMed:15170751};
DE   AltName: Full=Vc5.1 {ECO:0000303|PubMed:15170751};
DE   Flags: Precursor; Fragment;
OS   Conus victoriae (Queen Victoria cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=319920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], HYDROXYLATION AT PRO-49, AMIDATION AT ILE-53,
RP   MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=15170751; DOI=10.1002/jms.624;
RA   Jakubowski J.A., Keays D.A., Kelley W.P., Sandall D.W., Bingham J.-P.,
RA   Livett B.G., Gayler K.R., Sweedler J.V.;
RT   "Determining sequences and post-translational modifications of novel
RT   conotoxins in Conus victoriae using cDNA sequencing and mass
RT   spectrometry.";
RL   J. Mass Spectrom. 39:548-557(2004).
RN   [2]
RP   SYNTHESIS OF 44-53.
RX   PubMed=23567999; DOI=10.1016/j.bcp.2013.03.019;
RA   Petrel C., Hocking H.G., Reynaud M., Upert G., Favreau P., Biass D.,
RA   Paolini-Bertrand M., Peigneur S., Tytgat J., Gilles N., Hartley O.,
RA   Boelens R., Stocklin R., Servent D.;
RT   "Identification, structural and pharmacological characterization of tau-
RT   CnVA, a conopeptide that selectively interacts with somatostatin sst
RT   receptor.";
RL   Biochem. Pharmacol. 85:1663-1671(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15170751}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:15170751}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1090.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15170751};
CC   -!- MISCELLANEOUS: Does not have the ability to interact with the G-protein
CC       coupled somatostatin type 3 receptor (SSTR3).
CC       {ECO:0000305|PubMed:23567999}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P69765; -.
DR   ConoServer; 1549; VcVA precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Hydroxylation; Ion channel impairing toxin;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          <1..14
FT                   /evidence="ECO:0000255"
FT   PROPEP          15..42
FT                   /evidence="ECO:0000305|PubMed:15170751"
FT                   /id="PRO_0000035043"
FT   PEPTIDE         44..53
FT                   /note="Conotoxin vc5a"
FT                   /evidence="ECO:0000269|PubMed:15170751"
FT                   /id="PRO_0000035044"
FT   MOD_RES         49
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:15170751"
FT   MOD_RES         53
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:15170751"
FT   NON_TER         1
SQ   SEQUENCE   54 AA;  5952 MW;  223E186BD96112D6 CRC64;
     VILLLITSTP SVDARLKAKD NMPLASFHDN AKRTLQTRLI NTRCCPGKPC CRIG