ID   CT5B_CONAL              Reviewed;          11 AA.
AC   P58849;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 1.
DT   29-SEP-2021, entry version 51.
DE   RecName: Full=Conotoxin au5b {ECO:0000303|PubMed:10521453};
OS   Conus aulicus (Princely cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Darioconus.
OX   NCBI_TaxID=89437;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=10521453; DOI=10.1074/jbc.274.43.30664;
RA   Walker C.S., Steel D., Jacobsen R.B., Lirazan M.B., Cruz L.J., Hooper D.,
RA   Shetty R., DelaCruz R.C., Nielsen J.S., Zhou L.M., Bandyopadhyay P.,
RA   Craig A.G., Olivera B.M.;
RT   "The T-superfamily of conotoxins.";
RL   J. Biol. Chem. 274:30664-30671(1999).
RN   [2]
RP   ERRATUM OF PUBMED:10521453.
RA   Walker C.S., Steel D., Jacobsen R.B., Lirazan M.B., Cruz L.J., Hooper D.,
RA   Shetty R., DelaCruz R.C., Nielsen J.S., Zhou L.M., Bandyopadhyay P.,
RA   Craig A.G., Olivera B.M.;
RL   J. Biol. Chem. 274:36030-36030(1999).
CC   -!- FUNCTION: Causes dorsal fins drooping in fish. No effect is observed
CC       when injected into mice (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10521453}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:10521453}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1388.6; Method=LSI;
CC       Evidence={ECO:0000269|PubMed:10521453};
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   PIR; B59146; B59146.
DR   ConoServer; 1735; AuVB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012631; Toxin_26.
DR   Pfam; PF08097; Toxin_26; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..11
FT                   /note="Conotoxin au5b"
FT                   /id="PRO_0000044492"
SQ   SEQUENCE   11 AA;  1393 MW;  21A36775440042D7 CRC64;
     FCCPVIRYCC W