ID   CT5B_CONBY              Reviewed;          71 AA.
AC   P0DTJ5;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Conotoxin ba5b {ECO:0000303|PubMed:33916793};
DE   AltName: Full=Conotoxin ba5.1 {ECO:0000305};
DE   Contains:
DE     RecName: Full=Conotoxin ba5a {ECO:0000303|PubMed:33916793};
DE   Flags: Precursor;
OS   Conus bayani (Bayan's cone) (Stellaconus bayani).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Splinoconus.
OX   NCBI_TaxID=2070216;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 53-64, MASS SPECTROMETRY,
RP   SUBCELLULAR LOCATION, AND AMIDATION AT CYS-64.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=33916793; DOI=10.3390/md19040202;
RA   Rajaian Pushpabai R., Wilson Alphonse C.R., Mani R., Arun Apte D.,
RA   Franklin J.B.;
RT   "Diversity of Conopeptides and Conoenzymes from the Venom Duct of the
RT   Marine Cone Snail Conus bayani as Determined from Transcriptomic and
RT   Proteomic Analyses.";
RL   Mar. Drugs 19:0-0(2021).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33916793}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:33916793}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: [Conotoxin ba5a]: Mass=1016.6; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:33916793};
CC   -!- MASS SPECTROMETRY: [Conotoxin ba5b]: Mass=1103.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:33916793};
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..52
FT                   /evidence="ECO:0000305|PubMed:33916793"
FT                   /id="PRO_0000454986"
FT   PEPTIDE         53..64
FT                   /note="Conotoxin ba5b"
FT                   /evidence="ECO:0000269|PubMed:33916793"
FT                   /id="PRO_0000454987"
FT   PEPTIDE         54..64
FT                   /note="Conotoxin ba5a"
FT                   /evidence="ECO:0000269|PubMed:33916793"
FT                   /id="PRO_0000454988"
FT   PROPEP          66..71
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000454989"
FT   MOD_RES         64
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:33916793"
FT   DISULFID        54..63
FT                   /evidence="ECO:0000250|UniProtKB:P81755"
FT   DISULFID        55..64
FT                   /evidence="ECO:0000250|UniProtKB:P81755"
SQ   SEQUENCE   71 AA;  7852 MW;  DDCAD6F2CE598767 CRC64;
     MLCLPVFITL LLLVSPSAAL PVESELQRDL TQDSPKDFRI REPLLLSKMF DRSCCGSSNT
     GSCCGRYQRG S