CT5B_CONVC
ID CT5B_CONVC Reviewed; 55 AA.
AC P69768;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Conotoxin vc5b {ECO:0000303|PubMed:15538774};
DE AltName: Full=Vc5.4 {ECO:0000303|PubMed:15170751};
DE Flags: Precursor; Fragment;
OS Conus victoriae (Queen Victoria cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=319920;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=15170751; DOI=10.1002/jms.624;
RA Jakubowski J.A., Keays D.A., Kelley W.P., Sandall D.W., Bingham J.-P.,
RA Livett B.G., Gayler K.R., Sweedler J.V.;
RT "Determining sequences and post-translational modifications of novel
RT conotoxins in Conus victoriae using cDNA sequencing and mass
RT spectrometry.";
RL J. Mass Spectrom. 39:548-557(2004).
RN [2]
RP MASS SPECTROMETRY, AMIDATION AT GLN-53, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=15538774; DOI=10.1021/ac0494376;
RA Jakubowski J.A., Sweedler J.V.;
RT "Sequencing and mass profiling highly modified conotoxins using global
RT reduction/alkylation followed by mass spectrometry.";
RL Anal. Chem. 76:6541-6547(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15170751}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:15170751}.
CC -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC 'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC and AC P81755). {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=1335.4; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:15538774};
CC -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P69768; -.
DR ConoServer; 1548; VcVB precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR031565; T-conotoxin.
DR Pfam; PF16981; Chi-conotoxin; 1.
PE 1: Evidence at protein level;
KW Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Secreted; Signal; Toxin.
FT SIGNAL <1..15
FT /evidence="ECO:0000255"
FT PROPEP 16..41
FT /evidence="ECO:0000305"
FT /id="PRO_0000035049"
FT PEPTIDE 43..53
FT /note="Conotoxin vc5b"
FT /evidence="ECO:0000269|PubMed:15538774"
FT /id="PRO_0000035050"
FT MOD_RES 53
FT /note="Glutamine amide"
FT /evidence="ECO:0000269|PubMed:15538774"
FT NON_TER 1
SQ SEQUENCE 55 AA; 6021 MW; A6692A385D1FE654 CRC64;
VILLLLIASA PSVDAQPKTK DDVPLAPLHD NAKSALQHLN QRCCQTFYWC CGQGK