ID   CT5B_CONVR              Reviewed;          59 AA.
AC   P0C2B1; B4XT49;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Conotoxin ViVB {ECO:0000303|PubMed:16574176};
DE   AltName: Full=Vi5.2 {ECO:0000303|PubMed:17933431};
DE   Flags: Precursor;
OS   Conus virgo (Virgin cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus.
OX   NCBI_TaxID=89427;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17933431; DOI=10.1016/j.peptides.2007.08.026;
RA   Peng C., Wu X., Han Y., Yuan D., Chi C., Wang C.;
RT   "Identification of six novel T-1 conotoxins from Conus pulicarius by
RT   molecular cloning.";
RL   Peptides 28:2116-2124(2007).
RN   [2]
RP   PROTEIN SEQUENCE OF 47-58, PYROGLUTAMATE FORMATION AT GLN-47, AMIDATION AT
RP   VAL-58, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=16574176; DOI=10.1016/j.toxicon.2006.01.023;
RA   Quinton L., Le Caer J.-P., Vinh J., Gilles N., Chamot-Rooke J.;
RT   "Fourier transform mass spectrometry: a powerful tool for toxin analysis.";
RL   Toxicon 47:715-726(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16574176}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:16574176}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1328.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16574176};
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; EU090177; ABW77585.1; -; mRNA.
DR   AlphaFoldDB; P0C2B1; -.
DR   ConoServer; 2834; ViVB precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..46
FT                   /evidence="ECO:0000269|PubMed:16574176"
FT                   /id="PRO_0000316912"
FT   PEPTIDE         47..58
FT                   /note="Conotoxin ViVB"
FT                   /evidence="ECO:0000269|PubMed:16574176"
FT                   /id="PRO_0000271476"
FT   MOD_RES         47
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:16574176"
FT   MOD_RES         58
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:16574176"
SQ   SEQUENCE   59 AA;  6439 MW;  F0A549C1F16F2FC9 CRC64;
     MRCVPVFIIL LLLIPSAPSA AVQPKTEKDD VPLASFHDSA MRILSRQCCP TIPECCRVG