ID   CTA11_CONAO             Reviewed;          11 AA.
AC   P0CI23;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   22-APR-2020, entry version 19.
DE   RecName: Full=Chi-conotoxin-like Ar1311;
OS   Conus araneosus (Cobweb cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=101286;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE BONDS,
RP   HYDROXYLATION AT PRO-10, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20843009; DOI=10.1021/ac101867e;
RA   Gupta K., Kumar M., Balaram P.;
RT   "Disulfide bond assignments by mass spectrometry of native natural
RT   peptides: cysteine pairing in disulfide bonded conotoxins.";
RL   Anal. Chem. 82:8313-8319(2010).
CC   -!- FUNCTION: Chi-conotoxins inhibit the neuronal noradrenaline transporter
CC       (NET/SLC6A2). {ECO:0000250|UniProtKB:P58808}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20843009}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20843009}.
CC   -!- DOMAIN: The cysteine framework is X (CC-CX[hydroxyPro]C).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Neurotoxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..11
FT                   /note="Chi-conotoxin-like Ar1311"
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT                   /id="PRO_0000402419"
FT   MOD_RES         10
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT   DISULFID        2..11
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT   DISULFID        3..8
FT                   /evidence="ECO:0000269|PubMed:20843009"
SQ   SEQUENCE   11 AA;  1301 MW;  277AA974B6932B58 CRC64;
     RCCGYKMCHP C