ID   CTA48_CONAO             Reviewed;          12 AA.
AC   P0CI22;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   02-JUN-2021, entry version 24.
DE   RecName: Full=Chi-conotoxin-like Ar1248 {ECO:0000303|PubMed:20843009, ECO:0000305};
DE   AltName: Full=Conotoxin Ar1232 {ECO:0000303|PubMed:20843009};
OS   Conus araneosus (Cobweb cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=101286;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, DISULFIDE BONDS, HYDROXYLATION AT
RP   PRO-11, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20843009; DOI=10.1021/ac101867e;
RA   Gupta K., Kumar M., Balaram P.;
RT   "Disulfide bond assignments by mass spectrometry of native natural
RT   peptides: cysteine pairing in disulfide bonded conotoxins.";
RL   Anal. Chem. 82:8313-8319(2010).
CC   -!- FUNCTION: Inhibits the neuronal noradrenaline transporter (NET/SLC6A2).
CC       {ECO:0000250|UniProtKB:P58808}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20843009}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20843009}.
CC   -!- DOMAIN: The cysteine framework is X (CC-CX[hydroxyPro]C).
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1249.4; Method=Electrospray; Note=With
CC       hydroxylation.; Evidence={ECO:0000269|PubMed:20843009};
CC   -!- MASS SPECTROMETRY: Mass=1233.5; Method=MALDI; Note=Without
CC       hydroxylation.; Evidence={ECO:0000269|PubMed:20843009};
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   PDB; 2M62; NMR; -; A=1-12.
DR   PDBsum; 2M62; -.
DR   BMRB; P0CI22; -.
DR   SMR; P0CI22; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..12
FT                   /note="Chi-conotoxin-like Ar1248"
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT                   /id="PRO_0000402418"
FT   MOD_RES         11
FT                   /note="4-hydroxyproline; partial"
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT   DISULFID        3..12
FT                   /evidence="ECO:0000269|PubMed:20843009,
FT                   ECO:0007744|PDB:2M62"
FT   DISULFID        4..9
FT                   /evidence="ECO:0000269|PubMed:20843009,
FT                   ECO:0007744|PDB:2M62"
FT   STRAND          3..5
FT                   /evidence="ECO:0007829|PDB:2M62"
FT   STRAND          8..10
FT                   /evidence="ECO:0007829|PDB:2M62"
SQ   SEQUENCE   12 AA;  1237 MW;  277AB68722D5A2C8 CRC64;
     GVCCGVSFCY PC