CTA6A_CONMR
ID CTA6A_CONMR Reviewed; 11 AA.
AC P58807;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2002, sequence version 1.
DT 02-JUN-2021, entry version 62.
DE RecName: Full=Chi-conotoxin CMrVIA;
DE AltName: Full=Conotoxin CMrVIA;
DE AltName: Full=Lambda-conotoxin CMrVIA;
OS Conus marmoreus (Marble cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX NCBI_TaxID=42752;
RN [1]
RP PROTEIN SEQUENCE, HYDROXYLATION AT PRO-10, DISULFIDE BONDS, SYNTHESIS, MASS
RP SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=10988292; DOI=10.1074/jbc.m006354200;
RA Balaji R.A., Ohtake A., Sato K., Gopalakrishnakone P., Kini R.M.,
RA Seow K.T., Bay B.-H.;
RT "Lambda-conotoxins, a new family of conotoxins with unique disulfide
RT pattern and protein folding. Isolation and characterization from the venom
RT of Conus marmoreus.";
RL J. Biol. Chem. 275:39516-39522(2000).
RN [2]
RP STRUCTURE BY NMR, SYNTHESIS, HYDROXYLATION AT PRO-10, AND DISULFIDE BONDS.
RX PubMed=16903680; DOI=10.1021/bm060269w;
RA Kang T.S., Jois S.D.S., Kini R.M.;
RT "Solution structures of two structural isoforms of CMrVIA chi/lambda-
RT conotoxin.";
RL Biomacromolecules 7:2337-2346(2006).
CC -!- FUNCTION: Chi-conotoxins inhibit the neuronal noradrenaline transporter
CC (NET/SLC6A2). {ECO:0000250|UniProtKB:P58808}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10988292}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:10988292}.
CC -!- DOMAIN: The cysteine framework is X (CC-CX[hydroxyPro]C).
CC {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=1237.93; Mass_error=0.21; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:10988292};
CC -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR PDB; 2B5P; NMR; -; A=1-11.
DR PDB; 2B5Q; NMR; -; A=1-11.
DR PDBsum; 2B5P; -.
DR PDBsum; 2B5Q; -.
DR SMR; P58807; -.
DR EvolutionaryTrace; P58807; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW Neurotoxin; Secreted; Toxin.
FT PEPTIDE 1..11
FT /note="Chi-conotoxin CMrVIA"
FT /evidence="ECO:0000269|PubMed:10988292"
FT /id="PRO_0000044507"
FT MOD_RES 10
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:10988292,
FT ECO:0000269|PubMed:16903680"
FT DISULFID 2..11
FT /evidence="ECO:0000269|PubMed:16903680,
FT ECO:0000312|PDB:2B5P, ECO:0000312|PDB:2B5Q"
FT DISULFID 3..8
FT /evidence="ECO:0000269|PubMed:16903680,
FT ECO:0000312|PDB:2B5P, ECO:0000312|PDB:2B5Q"
FT TURN 4..6
FT /evidence="ECO:0007829|PDB:2B5Q"
SQ SEQUENCE 11 AA; 1226 MW; 277AAC60B7232B58 CRC64;
VCCGYKLCHP C