CTAG2_HUMAN
ID CTAG2_HUMAN Reviewed; 210 AA.
AC O75638; O75637; Q0VIL6; Q14CD6; Q2Z1N4; Q9BU80; Q9UJ89; Q9Y479;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Cancer/testis antigen 2;
DE Short=CT2;
DE AltName: Full=Autoimmunogenic cancer/testis antigen NY-ESO-2;
DE AltName: Full=Cancer/testis antigen 6.2;
DE Short=CT6.2;
DE AltName: Full=L antigen family member 1;
DE Short=LAGE-1;
GN Name=CTAG2; Synonyms=ESO2, LAGE1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LAGE-1A AND LAGE-1B).
RC TISSUE=Melanoma;
RX PubMed=9626360;
RX DOI=10.1002/(sici)1097-0215(19980610)76:6<903::aid-ijc22>3.0.co;2-1;
RA Lethe B.G., Lucas S., Michaux L., De Smet C., Godelaine D., Serrano A.,
RA De Plaen E., Boon T.;
RT "LAGE-1, a new gene with tumor specificity.";
RL Int. J. Cancer 76:903-908(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LAGE-1A AND LAGE-1B), AND VARIANTS
RP GLN-6 AND GLN-89.
RC TISSUE=Melanoma;
RX PubMed=10399963;
RX DOI=10.1002/(sici)1097-0215(19990730)82:3<442::aid-ijc19>3.0.co;2-z;
RA Aarnoudse C.A., Van den Doel P.B., Heemskerk B., Schrier P.I.;
RT "Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an
RT unexpected translation product of LAGE-1.";
RL Int. J. Cancer 82:442-448(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-6 AND GLN-89.
RX PubMed=11709543; DOI=10.1093/hmg/10.22.2557;
RA Aradhya S., Bardaro T., Galgoczy P., Yamagata T., Esposito T., Patlan H.,
RA Ciccodicola A., Kenwrick S., Platzer M., D'Urso M., Nelson D.L.;
RT "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb
RT duplication involving the NEMO and LAGE2 genes.";
RL Hum. Mol. Genet. 10:2557-2567(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAGE-1A), AND POLYMORPHISM.
RC TISSUE=Hepatoma, and Stomach cancer;
RX PubMed=17899192; DOI=10.1007/s00432-007-0312-z;
RA Shao Y., Sun Z.-Y., Sun S.-W., Zhao Y., Sin W.Y., Yuan Y.-H.,
RA Simpson A.J.G., Old L.J., Sang X.-T., Mao Y.-L., Xie Y., Huang J.-F.,
RA Zhao H.-T.;
RT "Identification and expression analysis of novel LAGE-1 alleles with single
RT nucleotide polymorphisms in cancer patients.";
RL J. Cancer Res. Clin. Oncol. 134:495-502(2008).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS GLN-6 AND
RP GLN-89.
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LAGE-1A AND LAGE-1B).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- INTERACTION:
CC O75638; Q15654: TRIP6; NbExp=4; IntAct=EBI-10188927, EBI-742327;
CC O75638; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-10188927, EBI-10173939;
CC O75638-2; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-12265122, EBI-4400025;
CC O75638-2; Q6ICB0: DESI1; NbExp=6; IntAct=EBI-12265122, EBI-2806959;
CC O75638-2; P32242: OTX1; NbExp=3; IntAct=EBI-12265122, EBI-740446;
CC O75638-2; P54646: PRKAA2; NbExp=3; IntAct=EBI-12265122, EBI-1383852;
CC O75638-2; P49901: SMCP; NbExp=3; IntAct=EBI-12265122, EBI-750494;
CC O75638-2; Q8NCE0: TSEN2; NbExp=3; IntAct=EBI-12265122, EBI-2559818;
CC O75638-2; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-12265122, EBI-741480;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=LAGE-1B; Synonyms=LAGE-1L;
CC IsoId=O75638-1; Sequence=Displayed;
CC Name=LAGE-1A; Synonyms=LAGE-1S;
CC IsoId=O75638-2; Sequence=VSP_004301;
CC -!- TISSUE SPECIFICITY: Testis and very low level in placenta and in some
CC uterus samples. Observed in 25-50% of tumor samples of melanomas, non-
CC small-cell lung carcinomas, bladder, prostate and head and neck
CC cancers.
CC -!- POLYMORPHISM: At least three different alleles exist. The allele
CC defined by Arg-6 and Glu-89 is associated with a risk of gastric
CC cancer. {ECO:0000269|PubMed:17899192}.
CC -!- SIMILARITY: Belongs to the CTAG/PCC1 family. {ECO:0000305}.
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DR EMBL; AJ223093; CAA11117.1; -; Genomic_DNA.
DR EMBL; AJ223093; CAA11116.1; -; Genomic_DNA.
DR EMBL; AJ223040; CAA11043.1; -; mRNA.
DR EMBL; AJ223041; CAA11044.1; -; mRNA.
DR EMBL; AJ012834; CAA10194.1; -; mRNA.
DR EMBL; AJ012835; CAA10196.1; -; mRNA.
DR EMBL; AY679088; AAV98584.1; -; mRNA.
DR EMBL; AY679089; AAV98585.1; -; mRNA.
DR EMBL; AC244107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF277315; AAL27015.1; -; Genomic_DNA.
DR EMBL; BC002833; AAH02833.1; -; mRNA.
DR EMBL; BC113998; AAI13999.1; -; mRNA.
DR EMBL; BC128045; AAI28046.1; -; mRNA.
DR CCDS; CCDS14759.1; -. [O75638-1]
DR CCDS; CCDS35455.1; -. [O75638-2]
DR RefSeq; NP_066274.2; NM_020994.4. [O75638-1]
DR RefSeq; NP_758965.2; NM_172377.4. [O75638-2]
DR AlphaFoldDB; O75638; -.
DR SMR; O75638; -.
DR BioGRID; 119058; 35.
DR IntAct; O75638; 9.
DR STRING; 9606.ENSP00000247306; -.
DR iPTMnet; O75638; -.
DR PhosphoSitePlus; O75638; -.
DR BioMuta; CTAG2; -.
DR jPOST; O75638; -.
DR MassIVE; O75638; -.
DR PaxDb; O75638; -.
DR PeptideAtlas; O75638; -.
DR PRIDE; O75638; -.
DR ProteomicsDB; 50134; -. [O75638-1]
DR ProteomicsDB; 50135; -. [O75638-2]
DR Antibodypedia; 31343; 153 antibodies from 24 providers.
DR DNASU; 30848; -.
DR Ensembl; ENST00000247306.4; ENSP00000247306.4; ENSG00000126890.14. [O75638-1]
DR Ensembl; ENST00000369585.4; ENSP00000358598.3; ENSG00000126890.14. [O75638-2]
DR GeneID; 30848; -.
DR KEGG; hsa:30848; -.
DR MANE-Select; ENST00000369585.4; ENSP00000358598.3; NM_172377.5; NP_758965.2. [O75638-2]
DR UCSC; uc004fmh.3; human. [O75638-1]
DR CTD; 30848; -.
DR DisGeNET; 30848; -.
DR GeneCards; CTAG2; -.
DR HGNC; HGNC:2492; CTAG2.
DR HPA; ENSG00000126890; Tissue enhanced (heart muscle, testis).
DR MIM; 300396; gene.
DR neXtProt; NX_O75638; -.
DR OpenTargets; ENSG00000126890; -.
DR PharmGKB; PA26994; -.
DR VEuPathDB; HostDB:ENSG00000126890; -.
DR eggNOG; ENOG502TM3F; Eukaryota.
DR GeneTree; ENSGT00410000025802; -.
DR HOGENOM; CLU_113770_0_0_1; -.
DR InParanoid; O75638; -.
DR OMA; PIRKELY; -.
DR OrthoDB; 1584653at2759; -.
DR PhylomeDB; O75638; -.
DR TreeFam; TF337064; -.
DR PathwayCommons; O75638; -.
DR SignaLink; O75638; -.
DR BioGRID-ORCS; 30848; 12 hits in 695 CRISPR screens.
DR ChiTaRS; CTAG2; human.
DR GenomeRNAi; 30848; -.
DR Pharos; O75638; Tbio.
DR PRO; PR:O75638; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O75638; protein.
DR Bgee; ENSG00000126890; Expressed in buccal mucosa cell and 113 other tissues.
DR Genevisible; O75638; HS.
DR GO; GO:0005813; C:centrosome; IDA:LIFEdb.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0070525; P:tRNA threonylcarbamoyladenosine metabolic process; IBA:GO_Central.
DR InterPro; IPR015419; CTAG/Pcc1.
DR PANTHER; PTHR31283; PTHR31283; 1.
DR Pfam; PF09341; Pcc1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..210
FT /note="Cancer/testis antigen 2"
FT /id="PRO_0000218923"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 135..210
FT /note="MSVRDQDREGAGRMRVVGWGLGSASPEGQKARDLRTPKHKVSEQRPGTPGPP
FT PPEGAQGDGCRGVAFNVMFSAPHI -> IRLTAADHRQLQLSISSCLQQLSLLMWITQC
FT FLPVFLAQAPSGQRR (in isoform LAGE-1A)"
FT /evidence="ECO:0000303|PubMed:10399963,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:17899192,
FT ECO:0000303|PubMed:9626360"
FT /id="VSP_004301"
FT VARIANT 6
FT /note="R -> Q (in dbSNP:rs17855367)"
FT /evidence="ECO:0000269|PubMed:10399963,
FT ECO:0000269|PubMed:11709543, ECO:0000269|PubMed:9626360"
FT /id="VAR_007855"
FT VARIANT 89
FT /note="E -> Q (in dbSNP:rs17328091)"
FT /evidence="ECO:0000269|PubMed:10399963,
FT ECO:0000269|PubMed:11709543, ECO:0000269|PubMed:9626360"
FT /id="VAR_007856"
FT VARIANT 99
FT /note="P -> A (in dbSNP:rs5987003)"
FT /id="VAR_057512"
FT CONFLICT 138
FT /note="R -> W (in Ref. 1; CAA11117)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 210 AA; 21090 MW; 8FB5BF04FB04E8BE CRC64;
MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA
PRGPHGGAAS AQDGRCPCGA RRPDSRLLEL HITMPFSSPM EAELVRRILS RDAAPLPRPG
AVLKDFTVSG NLLFMSVRDQ DREGAGRMRV VGWGLGSASP EGQKARDLRT PKHKVSEQRP
GTPGPPPPEG AQGDGCRGVA FNVMFSAPHI
