ID   CTC1_DANRE              Reviewed;        1205 AA.
AC   A0JMF1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=CST complex subunit CTC1;
DE   AltName: Full=Conserved telomere maintenance component 1;
GN   Name=ctc1; ORFNames=zgc:153125;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CST complex proposed to act as a specialized
CC       replication factor promoting DNA replication under conditions of
CC       replication stress or natural replication barriers such as the telomere
CC       duplex. The CST complex binds single-stranded DNA with high affinity in
CC       a sequence-independent manner, while isolated subunits bind DNA with
CC       low affinity by themselves. Initially the CST complex has been proposed
CC       to protect telomeres from DNA degradation. However, the CST complex has
CC       been shown to be involved in several aspects of telomere replication
CC       (By similarity). {ECO:0000250|UniProtKB:Q2NKJ3,
CC       ECO:0000250|UniProtKB:Q5SUQ9}.
CC   -!- SUBUNIT: Component of the CST complex. {ECO:0000250|UniProtKB:Q2NKJ3,
CC       ECO:0000250|UniProtKB:Q5SUQ9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2NKJ3,
CC       ECO:0000250|UniProtKB:Q5SUQ9}. Chromosome, telomere
CC       {ECO:0000250|UniProtKB:Q2NKJ3, ECO:0000250|UniProtKB:Q5SUQ9}.
CC   -!- SIMILARITY: Belongs to the CTC1 family. {ECO:0000305}.
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DR   EMBL; BC125854; AAI25855.1; -; mRNA.
DR   RefSeq; NP_001071213.1; NM_001077745.1.
DR   AlphaFoldDB; A0JMF1; -.
DR   SMR; A0JMF1; -.
DR   STRING; 7955.ENSDARP00000093415; -.
DR   PaxDb; A0JMF1; -.
DR   GeneID; 777638; -.
DR   KEGG; dre:777638; -.
DR   CTD; 80169; -.
DR   ZFIN; ZDB-GENE-061103-271; ctc1.
DR   eggNOG; ENOG502RBD3; Eukaryota.
DR   InParanoid; A0JMF1; -.
DR   OrthoDB; 163417at2759; -.
DR   PhylomeDB; A0JMF1; -.
DR   Reactome; R-DRE-174411; Polymerase switching on the C-strand of the telomere.
DR   Reactome; R-DRE-174430; Telomere C-strand synthesis initiation.
DR   PRO; PR:A0JMF1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:1990879; C:CST complex; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR   GO; GO:0045740; P:positive regulation of DNA replication; IBA:GO_Central.
DR   GO; GO:0010833; P:telomere maintenance via telomere lengthening; IBA:GO_Central.
DR   InterPro; IPR029156; CTC1.
DR   InterPro; IPR042617; CTC1-like.
DR   PANTHER; PTHR14865; PTHR14865; 1.
DR   Pfam; PF15489; CTC1; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..1205
FT                   /note="CST complex subunit CTC1"
FT                   /id="PRO_0000287184"
FT   REGION          303..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1205 AA;  133268 MW;  C73692D585F64D7D CRC64;
     MEEFLNNFKS YSRADQRWLS AVFEAVQQQF SPLLDSDGFS VARLAQSVVE KVQRAVGSDC
     ADLPVSYRIV SVSELIRDQR TACCSSLCWS SAHYRDQAKK AEQTLPNYKA LPRDNLLLIG
     FLCDGRADGK SEGEWRVRDA GGSVPCMMLK SSCLWLGRLM LFPTWNYIPQ NAPGAAGYLE
     LVDPPVCVTL EAMTFDPGGA LTEVMSVRHA AELLAHSCED QVCVCVGGQV CVVGPLLLIR
     GKRFFCLVLS DGGSSVALII RELKHQYWRQ CVCVGQSVWI SSLRVCSLGA LEGRRVLTDS
     CQSRLHPHTP LQESSEEQDT EDDTHTPADT THTLADATRT PADDTRLASD PAVRVKPSTI
     ISFKGTVTKI LNAEAGLYEL DGQVGLCLAY QPTQKWGGGL RPGAEIQLHN VHFTYQASAF
     APRAVLWACL RSSVQITAFS RLCSELQVTE PHGALQRLLL ERNLGPSQYL WLCYCQKAIA
     ERLSPRWVRP DRVCVVAGRL LDAVCDAEQK TKKKRNIYTE MIQEPHHCPI SMYCVRWPSA
     ALWSVQQLCV WMQREVWSSL SLPALLSASA PHMTALELNS ALRWSSVELR LEEASPDPLL
     LLGVLELQAE SATLQLRDHT HKLHCLCVCR DHSPNISTAW QGCLVCVRRC TLVMERFMKT
     NFPSWKHLDQ PSYITLKHCR VYLQLCMDDL IIISPSSSMS HQMAESKLTH GHTHRSCGES
     SKRLRSADAG VCERADSSAV CVSLLFRLEN KHGVTLQNVS ADTHTRQLGF KCRAVCVGGV
     QRWSHDPKNC RIQERERDGG GQTVELHFRG SCVRWFPVLH PGCVYRLIAL NTEDVGVLEA
     KGVSARGGVT QLSSPSLLLQ PQWRVHTLPE EPADAQAAAP ALMSVSEVLH SSSAPEVVSF
     HGIISQRITL QEDNEAQPKI KSVSPTADTQ EDLRVRLTVQ DAECPGLMVH VYLDLSCGLY
     TLGLITGAAL QVHHVQRKVS RACNVYCRSL PISYVSVTGL RSVCSGPAAA APPPPMMLLG
     SWASVGSQQC LVAQVKGHVV CVLSLRLQWI CSLCGSIFTQ TTCGRTHPPC DSTSAVFQAE
     AKVVLEDGTG EAHVWFSSES VCGLLMLNAV QWEGLQRLVR VKGHVKVYTR GRTMTCDDSP
     DDSIVQYLSC LCSSVSVCRQ IHVTCRRRAQ KTGKSQLRKV HRGQTEFICK FPPALQLQCQ
     HIHTR