CTCFL_HUMAN
ID CTCFL_HUMAN Reviewed; 663 AA.
AC Q8NI51; A0S6W1; A1L4C6; A6XGL8; A6XGM2; A6XGM3; A6XGM8; A6XGN0; A6XGN1;
AC A6XGN2; A6XGN3; A6XGN4; E7EQ27; E7EUE3; E9PBA9; Q5JUG4; Q9BZ30; Q9NQJ3;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Transcriptional repressor CTCFL;
DE AltName: Full=Brother of the regulator of imprinted sites;
DE AltName: Full=CCCTC-binding factor;
DE AltName: Full=CTCF paralog;
DE AltName: Full=CTCF-like protein;
DE AltName: Full=Cancer/testis antigen 27;
DE Short=CT27;
DE AltName: Full=Zinc finger protein CTCF-T;
GN Name=CTCFL; Synonyms=BORIS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10 AND 11),
RP FUNCTION, AND VARIANT ALA-177.
RC TISSUE=Testis;
RX PubMed=12011441; DOI=10.1073/pnas.092123699;
RA Loukinov D.I., Pugacheva E., Vatolin S., Pack S.D., Moon H., Chernukhin I.,
RA Mannan P., Larsson E., Kanduri C., Vostrov A.A., Cui H., Niemitz E.L.,
RA Rasko J.E.J., Docquier F.M., Kistler M., Breen J.J., Zhuang Z.,
RA Quitschke W.W., Renkawitz R., Klenova E.M., Feinberg A.P., Ohlsson R.,
RA Morse H.C. III, Lobanenkov V.V.;
RT "BORIS, a novel male germ-line-specific protein associated with epigenetic
RT reprogramming events, shares the same 11-zinc-finger domain with CTCF, the
RT insulator protein involved in reading imprinting marks in the soma.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:6806-6811(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17048991; DOI=10.1371/journal.pbio.0040355;
RA Jelinic P., Stehle J.-C., Shaw P.;
RT "The testis-specific factor CTCFL cooperates with the protein
RT methyltransferase PRMT7 in H19 imprinting control region methylation.";
RL PLoS Biol. 4:E355-E355(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ALA-177.
RC TISSUE=Testis;
RX PubMed=17962299; DOI=10.1093/nar/gkm896;
RA Renaud S., Pugacheva E.M., Delgado M.D., Braunschweig R., Abdullaev Z.,
RA Loukinov D., Benhattar J., Lobanenkov V.;
RT "Expression of the CTCF-paralogous cancer-testis gene, brother of the
RT regulator of imprinted sites (BORIS), is regulated by three alternative
RT promoters modulated by CpG methylation and by CTCF and p53 transcription
RT factors.";
RL Nucleic Acids Res. 35:7372-7388(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-177.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-177.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP REVIEW.
RX PubMed=12191639; DOI=10.1016/s1044-579x(02)00060-3;
RA Klenova E.M., Morse H.C. III, Ohlsson R., Lobanenkov V.V.;
RT "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics
RT of normal biology and cancer.";
RL Semin. Cancer Biol. 12:399-414(2002).
RN [9]
RP FUNCTION.
RX PubMed=18413740; DOI=10.1158/0008-5472.can-07-6654;
RA Sun L., Huang L., Nguyen P., Bisht K.S., Bar-Sela G., Ho A.S.,
RA Bradbury C.M., Yu W., Cui H., Lee S., Trepel J.B., Feinberg A.P., Gius D.;
RT "DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment
RT of CTCFL/BORIS and modulation of promoter histone methylation.";
RL Cancer Res. 68:2726-2735(2008).
RN [10]
RP FUNCTION, AND INTERACTION WITH BAG6/BAT3 AND SETD1A.
RX PubMed=18765639; DOI=10.1128/mcb.00568-08;
RA Nguyen P., Bar-Sela G., Sun L., Bisht K.S., Cui H., Kohn E., Feinberg A.P.,
RA Gius D.;
RT "BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone
RT dimethylation and gene expression.";
RL Mol. Cell. Biol. 28:6720-6729(2008).
CC -!- FUNCTION: Testis-specific DNA binding protein responsible for insulator
CC function, nuclear architecture and transcriptional control, which
CC probably acts by recruiting epigenetic chromatin modifiers. Plays a key
CC role in gene imprinting in male germline, by participating in the
CC establishment of differential methylation at the IGF2/H19 imprinted
CC control region (ICR). Directly binds the unmethylated H19 ICR and
CC recruits the PRMT7 methyltransferase, leading to methylate histone H4
CC 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA
CC methyltransferases at these sites (By similarity). Seems to act as
CC tumor suppressor. In association with DNMT1 and DNMT3B, involved in
CC activation of BAG1 gene expression by binding to its promoter. Required
CC for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
CC {ECO:0000250, ECO:0000269|PubMed:12011441, ECO:0000269|PubMed:18413740,
CC ECO:0000269|PubMed:18765639}.
CC -!- SUBUNIT: Interacts with histones, PRMT7 and SETD1A. Interacts (via N-
CC terminus) with BAG6/BAT3. {ECO:0000269|PubMed:18765639}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=11;
CC Name=1;
CC IsoId=Q8NI51-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NI51-2; Sequence=VSP_045158;
CC Name=3;
CC IsoId=Q8NI51-3; Sequence=VSP_045160;
CC Name=4;
CC IsoId=Q8NI51-4; Sequence=VSP_045157, VSP_045159;
CC Name=5;
CC IsoId=Q8NI51-5; Sequence=VSP_045156, VSP_045159;
CC Name=6;
CC IsoId=Q8NI51-6; Sequence=VSP_045155, VSP_045160;
CC Name=7;
CC IsoId=Q8NI51-7; Sequence=VSP_047059;
CC Name=8;
CC IsoId=Q8NI51-8; Sequence=VSP_047058;
CC Name=9;
CC IsoId=Q8NI51-9; Sequence=VSP_047725, VSP_047726;
CC Name=10;
CC IsoId=Q8NI51-10; Sequence=VSP_045156, VSP_045160;
CC Name=11;
CC IsoId=Q8NI51-11; Sequence=VSP_045155, VSP_054899;
CC -!- TISSUE SPECIFICITY: Testis specific. Specifically expressed in primary
CC spermatocytes.
CC -!- DEVELOPMENTAL STAGE: Is up-regulated in primary spermatocytes
CC (expression overlapping with the genome-wide erasure of methylation) to
CC become silenced on activation of CTCF in post-meiotic germline cells
CC (expression corresponding to DNA remethylation).
CC -!- SIMILARITY: Belongs to the CTCF zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AF336042; AAM28645.1; -; mRNA.
DR EMBL; AY071919; AAL61541.1; -; mRNA.
DR EMBL; DQ294738; ABB92839.1; -; mRNA.
DR EMBL; DQ778124; ABH10106.1; -; mRNA.
DR EMBL; DQ778108; ABH10090.1; -; mRNA.
DR EMBL; DQ778109; ABH10091.1; -; mRNA.
DR EMBL; DQ778110; ABH10092.1; -; mRNA.
DR EMBL; DQ778111; ABH10093.1; -; mRNA.
DR EMBL; DQ778112; ABH10094.1; -; mRNA.
DR EMBL; DQ778115; ABH10097.1; -; mRNA.
DR EMBL; DQ778116; ABH10098.1; -; mRNA.
DR EMBL; DQ778121; ABH10103.2; -; mRNA.
DR EMBL; DQ778123; ABH10105.1; -; mRNA.
DR EMBL; DQ778125; ABH10107.2; -; mRNA.
DR EMBL; DQ778126; ABH10108.1; -; mRNA.
DR EMBL; DQ778127; ABH10109.1; -; mRNA.
DR EMBL; AK128070; BAG54626.1; -; mRNA.
DR EMBL; AL035541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL160176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75518.1; -; Genomic_DNA.
DR EMBL; BC130486; AAI30487.1; -; mRNA.
DR CCDS; CCDS13459.1; -. [Q8NI51-1]
DR CCDS; CCDS58776.1; -. [Q8NI51-6]
DR CCDS; CCDS58777.1; -. [Q8NI51-5]
DR CCDS; CCDS58778.1; -. [Q8NI51-4]
DR CCDS; CCDS58779.1; -. [Q8NI51-8]
DR CCDS; CCDS58780.1; -. [Q8NI51-7]
DR CCDS; CCDS58781.1; -. [Q8NI51-3]
DR CCDS; CCDS58782.1; -. [Q8NI51-2]
DR CCDS; CCDS68161.1; -. [Q8NI51-11]
DR CCDS; CCDS68162.1; -. [Q8NI51-10]
DR RefSeq; NP_001255969.1; NM_001269040.1. [Q8NI51-1]
DR RefSeq; NP_001255970.1; NM_001269041.1. [Q8NI51-1]
DR RefSeq; NP_001255971.1; NM_001269042.1.
DR RefSeq; NP_001255972.1; NM_001269043.1. [Q8NI51-7]
DR RefSeq; NP_001255973.1; NM_001269044.1. [Q8NI51-3]
DR RefSeq; NP_001255974.1; NM_001269045.1.
DR RefSeq; NP_001255975.1; NM_001269046.1. [Q8NI51-8]
DR RefSeq; NP_001255976.1; NM_001269047.1. [Q8NI51-2]
DR RefSeq; NP_001255977.1; NM_001269048.1. [Q8NI51-4]
DR RefSeq; NP_001255978.1; NM_001269049.1. [Q8NI51-10]
DR RefSeq; NP_001255979.1; NM_001269050.1. [Q8NI51-5]
DR RefSeq; NP_001255980.1; NM_001269051.1.
DR RefSeq; NP_001255981.1; NM_001269052.1.
DR RefSeq; NP_001255983.1; NM_001269054.1. [Q8NI51-6]
DR RefSeq; NP_001255984.1; NM_001269055.1. [Q8NI51-11]
DR RefSeq; NP_542185.2; NM_080618.3. [Q8NI51-1]
DR AlphaFoldDB; Q8NI51; -.
DR SMR; Q8NI51; -.
DR BioGRID; 126653; 38.
DR IntAct; Q8NI51; 15.
DR STRING; 9606.ENSP00000415579; -.
DR iPTMnet; Q8NI51; -.
DR PhosphoSitePlus; Q8NI51; -.
DR BioMuta; CTCFL; -.
DR DMDM; 313104098; -.
DR EPD; Q8NI51; -.
DR jPOST; Q8NI51; -.
DR MassIVE; Q8NI51; -.
DR MaxQB; Q8NI51; -.
DR PaxDb; Q8NI51; -.
DR PeptideAtlas; Q8NI51; -.
DR PRIDE; Q8NI51; -.
DR ProteomicsDB; 1764; -.
DR ProteomicsDB; 1765; -.
DR ProteomicsDB; 1766; -.
DR ProteomicsDB; 1767; -.
DR ProteomicsDB; 1768; -.
DR ProteomicsDB; 1769; -.
DR ProteomicsDB; 1770; -.
DR ProteomicsDB; 18412; -.
DR ProteomicsDB; 73832; -. [Q8NI51-1]
DR Antibodypedia; 744; 271 antibodies from 33 providers.
DR DNASU; 140690; -.
DR Ensembl; ENST00000243914.8; ENSP00000243914.3; ENSG00000124092.13. [Q8NI51-1]
DR Ensembl; ENST00000371196.6; ENSP00000360239.2; ENSG00000124092.13. [Q8NI51-1]
DR Ensembl; ENST00000422109.6; ENSP00000413713.2; ENSG00000124092.13. [Q8NI51-9]
DR Ensembl; ENST00000422869.6; ENSP00000399061.2; ENSG00000124092.13. [Q8NI51-2]
DR Ensembl; ENST00000423479.7; ENSP00000415579.2; ENSG00000124092.13. [Q8NI51-7]
DR Ensembl; ENST00000429804.7; ENSP00000415329.2; ENSG00000124092.13. [Q8NI51-8]
DR Ensembl; ENST00000432255.6; ENSP00000409344.2; ENSG00000124092.13. [Q8NI51-4]
DR Ensembl; ENST00000433949.7; ENSP00000392034.3; ENSG00000124092.13. [Q8NI51-10]
DR Ensembl; ENST00000502686.6; ENSP00000437999.1; ENSG00000124092.13. [Q8NI51-6]
DR Ensembl; ENST00000539382.5; ENSP00000439998.1; ENSG00000124092.13. [Q8NI51-5]
DR Ensembl; ENST00000608263.5; ENSP00000476783.1; ENSG00000124092.13. [Q8NI51-1]
DR Ensembl; ENST00000608440.5; ENSP00000477488.1; ENSG00000124092.13. [Q8NI51-3]
DR Ensembl; ENST00000608903.5; ENSP00000476718.1; ENSG00000124092.13. [Q8NI51-11]
DR Ensembl; ENST00000609232.5; ENSP00000476398.1; ENSG00000124092.13. [Q8NI51-1]
DR GeneID; 140690; -.
DR KEGG; hsa:140690; -.
DR MANE-Select; ENST00000243914.8; ENSP00000243914.3; NM_001386993.1; NP_001373922.1.
DR UCSC; uc010giw.2; human. [Q8NI51-1]
DR CTD; 140690; -.
DR DisGeNET; 140690; -.
DR GeneCards; CTCFL; -.
DR HGNC; HGNC:16234; CTCFL.
DR HPA; ENSG00000124092; Tissue enriched (testis).
DR MIM; 607022; gene.
DR neXtProt; NX_Q8NI51; -.
DR OpenTargets; ENSG00000124092; -.
DR PharmGKB; PA26999; -.
DR VEuPathDB; HostDB:ENSG00000124092; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161524; -.
DR HOGENOM; CLU_643978_0_0_1; -.
DR InParanoid; Q8NI51; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8NI51; -.
DR TreeFam; TF106430; -.
DR PathwayCommons; Q8NI51; -.
DR SignaLink; Q8NI51; -.
DR SIGNOR; Q8NI51; -.
DR BioGRID-ORCS; 140690; 11 hits in 1101 CRISPR screens.
DR ChiTaRS; CTCFL; human.
DR GeneWiki; CTCFL; -.
DR GenomeRNAi; 140690; -.
DR Pharos; Q8NI51; Tbio.
DR PRO; PR:Q8NI51; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8NI51; protein.
DR Bgee; ENSG00000124092; Expressed in secondary oocyte and 55 other tissues.
DR ExpressionAtlas; Q8NI51; baseline and differential.
DR Genevisible; Q8NI51; HS.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR GO; GO:0016571; P:histone methylation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006349; P:regulation of gene expression by genomic imprinting; ISS:UniProtKB.
DR GO; GO:0051569; P:regulation of histone H3-K4 methylation; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Cell cycle; Chromatin regulator;
KW Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..663
FT /note="Transcriptional repressor CTCFL"
FT /id="PRO_0000047226"
FT ZN_FING 257..279
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..336
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..421
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..451
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 458..480
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 486..508
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 514..537
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 546..568
FT /note="C2H2-type 11; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 24..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..262
FT /note="Missing (in isoform 6 and isoform 11)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_045155"
FT VAR_SEQ 1..205
FT /note="Missing (in isoform 5 and isoform 10)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_045156"
FT VAR_SEQ 354..497
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_045157"
FT VAR_SEQ 394..427
FT /note="GEKPYECHICHTRFTQSGTMKIHILQKHGENVPK -> EATSKRSLQEIPRC
FT KFHPDCLQMLQVWQRLFPLD (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_047725"
FT VAR_SEQ 395..444
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_047058"
FT VAR_SEQ 428..663
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_047726"
FT VAR_SEQ 559..663
FT /note="INLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAA
FT NGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK -> VL
FT Y (in isoform 11)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_054899"
FT VAR_SEQ 560..663
FT /note="NLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAAN
FT GDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK -> TSK
FT WSGLKPQTFIT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_045158"
FT VAR_SEQ 560..663
FT /note="NLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAAN
FT GDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK -> LWV
FT GNSEVAELGGPGSGPLLRLQSGCPPGLHHPKAGLGPEDPLPGQLRHTTAGTGLSSLLQG
FT PLCRAA (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_045159"
FT VAR_SEQ 614..663
FT /note="EAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK
FT -> GVISAHRNLCLLGSSDSHASVSGAGITDARHHAWLIVLLFLVEMGFYHVSHS (in
FT isoform 3, isoform 6 and isoform 10)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_045160"
FT VAR_SEQ 663
FT /note="K -> NSAGCTGRMMLVSAWLLGRPQETYNQGRRRRGSRRVTW (in
FT isoform 7)"
FT /evidence="ECO:0000303|PubMed:12011441"
FT /id="VSP_047059"
FT VARIANT 50
FT /note="E -> Q (in dbSNP:rs6070128)"
FT /id="VAR_023213"
FT VARIANT 177
FT /note="T -> A (in dbSNP:rs6025606)"
FT /evidence="ECO:0000269|PubMed:12011441,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17962299"
FT /id="VAR_023214"
FT VARIANT 448
FT /note="R -> H (in dbSNP:rs6092491)"
FT /id="VAR_057374"
FT VARIANT 525
FT /note="Q -> E (in dbSNP:rs6070122)"
FT /id="VAR_032766"
FT CONFLICT 613
FT /note="Missing (in Ref. 2; AAL61541)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 663 AA; 75747 MW; 9351E1A85173D085 CRC64;
MAATEISVLS EQFTKIKELE LMPEKGLKEE EKDGVCREKD HRSPSELEAE RTSGAFQDSV
LEEEVELVLA PSEESEKYIL TLQTVHFTSE AVELQDMSLL SIQQQEGVQV VVQQPGPGLL
WLEEGPRQSL QQCVAISIQQ ELYSPQEMEV LQFHALEENV MVASEDSKLA VSLAETTGLI
KLEEEQEKNQ LLAERTKEQL FFVETMSGDE RSDEIVLTVS NSNVEEQEDQ PTAGQADAEK
AKSTKNQRKT KGAKGTFHCD VCMFTSSRMS SFNRHMKTHT SEKPHLCHLC LKTFRTVTLL
RNHVNTHTGT RPYKCNDCNM AFVTSGELVR HRRYKHTHEK PFKCSMCKYA SVEASKLKRH
VRSHTGERPF QCCQCSYASR DTYKLKRHMR THSGEKPYEC HICHTRFTQS GTMKIHILQK
HGENVPKYQC PHCATIIARK SDLRVHMRNL HAYSAAELKC RYCSAVFHER YALIQHQKTH
KNEKRFKCKH CSYACKQERH MTAHIRTHTG EKPFTCLSCN KCFRQKQLLN AHFRKYHDAN
FIPTVYKCSK CGKGFSRWIN LHRHSEKCGS GEAKSAASGK GRRTRKRKQT ILKEATKGQK
EAAKGWKEAA NGDEAAAEEA STTKGEQFPG EMFPVACRET TARVKEEVDE GVTCEMLLNT
MDK
