ID   CTDA_CONTE              Reviewed;          58 AA.
AC   Q9BPH1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Conotoxin TxXIIIA {ECO:0000303|PubMed:19457344};
DE   Flags: Precursor;
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
RN   [2]
RP   PROTEIN SEQUENCE OF 47-58, SUBUNIT, SUBCELLULAR LOCATION, DISULFIDE BONDS,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=19457344; DOI=10.1016/j.jprot.2009.01.021;
RA   Quinton L., Gilles N., De Pauw E.;
RT   "TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile
RT   venom.";
RL   J. Proteomics 72:219-226(2009).
RN   [3]
RP   PROTEIN SEQUENCE OF 47-58, SUBUNIT, SUBCELLULAR LOCATION, MASS
RP   SPECTROMETRY, AND DISULFIDE BONDS.
RC   TISSUE=Venom;
RX   PubMed=19380747; DOI=10.1073/pnas.0900745106;
RA   Ueberheide B.M., Fenyo D., Alewood P.F., Chait B.T.;
RT   "Rapid sensitive analysis of cysteine rich peptide venom components.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:6910-6915(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=22709442; DOI=10.1021/pr300312h;
RA   Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA   Yates J.R. III, Bern M.;
RT   "Constrained de novo sequencing of conotoxins.";
RL   J. Proteome Res. 11:4191-4200(2012).
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:19380747,
CC       ECO:0000269|PubMed:19457344}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19380747,
CC       ECO:0000269|PubMed:19457344, ECO:0000269|PubMed:22709442}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19380747, ECO:0000305|PubMed:19457344}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: 5 disulfide bonds are present in each homodimer: two intrachain
CC       disulfide bonds per subunit, and one interchain disulfide bond linking
CC       the two subunits.
CC   -!- MASS SPECTROMETRY: Mass=2784.722; Method=MALDI; Note=Homodimer.;
CC       Evidence={ECO:0000269|PubMed:19457344};
CC   -!- MASS SPECTROMETRY: Mass=2784.716; Mass_error=0.02; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19380747};
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; AF214956; AAG60384.1; -; mRNA.
DR   AlphaFoldDB; Q9BPH1; -.
DR   ConoServer; 643; TxXIIIA precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..46
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000370229"
FT   PEPTIDE         47..58
FT                   /note="Conotoxin TxXIIIA"
FT                   /evidence="ECO:0000269|PubMed:19380747,
FT                   ECO:0000269|PubMed:19457344"
FT                   /id="PRO_0000370230"
SQ   SEQUENCE   58 AA;  6563 MW;  D8B7537B6B516BBA CRC64;
     MRCLPVFVIL LLLIASVPSV DAELKAKDDM PQASFHDNAE RDQQKKTSDC CFYHNCCC