ID   CTEN1_CUPSA             Reviewed;         140 AA.
AC   P86798; P86801;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Ctenidin-1 {ECO:0000303|PubMed:20369272};
DE   AltName: Full=Ctenidin-2;
DE   Flags: Precursor;
OS   Cupiennius salei (American wandering spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Cupiennius.
OX   NCBI_TaxID=6928;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PROTEIN SEQUENCE OF 20-39,
RP   FUNCTION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT GLY-138.
RC   TISSUE=Hemocyte {ECO:0000269|PubMed:20369272};
RX   PubMed=20369272; DOI=10.1007/s00018-010-0364-0;
RA   Baumann T., Kampfer U., Schurch S., Schaller J., Largiader C., Nentwig W.,
RA   Kuhn-Nentwig L.;
RT   "Ctenidins: antimicrobial glycine-rich peptides from the hemocytes of the
RT   spider Cupiennius salei.";
RL   Cell. Mol. Life Sci. 67:2787-2798(2010).
CC   -!- FUNCTION: Antimicrobial protein with bacteriostatic activity against
CC       the Gram-negative bacterium E.coli, and very weak activity against the
CC       Gram-positive bacterium S.aureus. Lacks activity against the yeast
CC       C.albicans. {ECO:0000269|PubMed:20369272}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8I948}.
CC   -!- TISSUE SPECIFICITY: Expressed in hemocytes (at protein level).
CC       {ECO:0000269|PubMed:20369272}.
CC   -!- MASS SPECTROMETRY: Mass=9507.372; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:20369272};
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DR   AlphaFoldDB; P86798; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:20369272"
FT   CHAIN           20..138
FT                   /note="Ctenidin-1"
FT                   /evidence="ECO:0000269|PubMed:20369272"
FT                   /id="PRO_0000401097"
FT   MOD_RES         138
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:20369272"
FT   CONFLICT        105..114
FT                   /note="Missing (in Ref. 1; AA seq)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   140 AA;  11750 MW;  27E5D13976BFE0B9 CRC64;
     MKHLIPLIVM ASVVLAVYAD RGYGGGRRGG GYGGGGYGGG GYGGGGGGYG GGVGGGRGGG
     GGLGGGRGGG GGVIDGKDDV GLGGGGYGGG LGGGQGGGGG LGGGQGGGGG LGGGRGGGGY
     GGGGGGYGGG KYGGGKYGGK