CTEN3_CUPSA
ID CTEN3_CUPSA Reviewed; 142 AA.
AC P86797;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 25-MAY-2022, entry version 9.
DE RecName: Full=Ctenidin-3 {ECO:0000303|PubMed:20369272};
DE Flags: Precursor;
OS Cupiennius salei (American wandering spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Cupiennius.
OX NCBI_TaxID=6928;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20-39, FUNCTION,
RP TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT TYR-139.
RC TISSUE=Hemocyte {ECO:0000269|PubMed:20369272};
RX PubMed=20369272; DOI=10.1007/s00018-010-0364-0;
RA Baumann T., Kampfer U., Schurch S., Schaller J., Largiader C., Nentwig W.,
RA Kuhn-Nentwig L.;
RT "Ctenidins: antimicrobial glycine-rich peptides from the hemocytes of the
RT spider Cupiennius salei.";
RL Cell. Mol. Life Sci. 67:2787-2798(2010).
CC -!- FUNCTION: Antimicrobial protein with bacteriostatic activity against
CC the Gram-negative bacterium E.coli, and very weak activity against the
CC Gram-positive bacterium S.aureus. Lacks activity against the yeast
CC C.albicans. {ECO:0000269|PubMed:20369272}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8I948}.
CC -!- TISSUE SPECIFICITY: Expressed in hemocytes (at protein level).
CC {ECO:0000269|PubMed:20369272}.
CC -!- MASS SPECTROMETRY: Mass=9564.373; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:20369272};
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DR AlphaFoldDB; P86797; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255, ECO:0000269|PubMed:20369272"
FT CHAIN 20..139
FT /note="Ctenidin-3"
FT /evidence="ECO:0000269|PubMed:20369272"
FT /id="PRO_0000401098"
FT MOD_RES 139
FT /note="Tyrosine amide"
FT /evidence="ECO:0000269|PubMed:20369272"
SQ SEQUENCE 142 AA; 11963 MW; DA984B4FB573DC19 CRC64;
MKHLIPLIVM ASVVLAVYAD RGYGGGRRGG GYGGGGYGGG GGGYGGGGGG YGGGVGGGRG
GGGGLGGGRG GGGGVIDGKD DVGLGGGGYG GGLGGGQGGG GGLGGGQGGG GGLGGGRGGG
GYGGGGGGYG GGKYGGGKYG RK