ID   CTF18_EMENI             Reviewed;         993 AA.
AC   P0C1D3; C8V1M9; Q5AYD6;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Chromosome transmission fidelity protein 18;
GN   Name=ctf18; Synonyms=chl12; ORFNames=AN6694;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Essential for the fidelity of chromosome transmission.
CC       Required for the DNA replication block checkpoint. Replication factor C
CC       (RFC) complex has an essential but redundant activity in sister
CC       chromatid cohesion establishment (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. CTF18
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA58512.1; Type=Erroneous gene model prediction; Note=The predicted gene AN6694 has been split into 2 genes: AN6694 and AN11898.; Evidence={ECO:0000305};
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DR   EMBL; AACD01000112; EAA58512.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001301; CBF71262.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0C1D3; -.
DR   STRING; 162425.CADANIAP00007479; -.
DR   EnsemblFungi; CBF71262; CBF71262; ANIA_06694.
DR   EnsemblFungi; EAA58512; EAA58512; AN6694.2.
DR   VEuPathDB; FungiDB:AN6694; -.
DR   eggNOG; KOG1969; Eukaryota.
DR   HOGENOM; CLU_004894_0_0_1; -.
DR   InParanoid; P0C1D3; -.
DR   OMA; SYEDPMV; -.
DR   OrthoDB; 307415at2759; -.
DR   Proteomes; UP000000560; Chromosome I.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; DNA replication; DNA-binding; Nucleotide-binding;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..993
FT                   /note="Chromosome transmission fidelity protein 18"
FT                   /id="PRO_0000235294"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..915
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         321..328
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   993 AA;  110115 MW;  3200FBC00F53CC68 CRC64;
     MPFISSAELS SRATPPDLQK RKYGEQSQPS EPKRQKIMGG FLDDDDDDDH DGLEAFNEAQ
     YQSEFEIQEQ RVDLPQISQS GSRAEPKRPK IMGGFLDNDD DDDDGLEAFN DAHLESQIDT
     QEQPVKLTEV SRSQSTLESV VINSVTERST IVPAYAPPNI SPTSVKIKTC NGKALNVPLK
     KPSARVSYER LIASRSTTAP GRAQKSYYGI DIHSLLNESA KEVKAAEAPK PAPVADVRPS
     IEAPIGDKRS KKLSTAMWTE KYRARKYTEL IGDERTNRSI LRWLRGWDPI VYPSLARAKQ
     NKKYNNDEEE RPHRKVLLLC GPPGLGKTTL AHVCARQAGY EVLEINASDE RSRDVVKGRI
     RDALGTENVK GMNVELGEQK VRKVGRPVCV VVDEVDGVVS GSGGSGEGGF MKALTDLVLL
     DQRNSARTSE RASDGRKRKG DNFRFLRPLI LVCNDVYHAS LRPLRQSSVA EIIHVRQAPL
     ENVVSRMKSI FTLEGIPSDS DGVRRLCEAS WGLAKRKQRG VRSTGAAEGD IRSVLVAAEW
     VAHKLRNESS APLRLTRNWL EQRVLADAGG GSFFKGMNRG GVRDIVDRVF TEGAGFPDVP
     LGDESLQDPY DRSEAVSVDV ANIKKRHAIR RLCEMVDASG DHDRCTSECF SSYPLQPYQD
     DTFLTKPNAA YDWLHFHDTI SSRIYSAHDW ELGAYLSQAT SAFHLLFATA QGKAQQQYRE
     IDEEEEEAHP FSGPRADYAA FEATKQNQAI LSTFQSSFSA PLLRLFRSSN NVATELIPNV
     IRMLSPDIKP VVVRGSEQKS VASVRKESER ALVQSAVRVM TGLGVTFEKV RIENEGGGHG
     GWAYRMEPPL DALVSFSKVP GFSSATNPVR YAVRQVLDQE YRKESIRKNS ENLSSTGSKK
     STTKSDDIET PANPAEAAKL KYGTAVKRDF FGRIIQDRVP SPQEDMEQAL SRKAKSAQQE
     LSSAGRKVWV TYHDGFSNAV RKPISMAELL SGL