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CTF18_MOUSE
ID   CTF18_MOUSE             Reviewed;         969 AA.
AC   Q8BIW9; Q8R1R7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Chromosome transmission fidelity protein 18 homolog;
GN   Name=Chtf18; Synonyms=Ctf18;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Chromosome cohesion factor involved in sister chromatid
CC       cohesion and fidelity of chromosome transmission. Component of one of
CC       the cell nuclear antigen loader complexes, CTF18-replication factor C
CC       (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and
CC       RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs
CC       and has weak ATPase activity that is stimulated by the presence of
CC       primed DNA, replication protein A (RPA) and by proliferating cell
CC       nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-
CC       dependent loading of PCNA onto primed and gapped DNA. Interacts with
CC       and stimulates DNA polymerase POLH. During DNA repair synthesis,
CC       involved in loading DNA polymerase POLE at the sites of local damage.
CC       {ECO:0000250|UniProtKB:Q8WVB6}.
CC   -!- SUBUNIT: Component of the CTF18-RFC complex, which consists of CTF18,
CC       CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. During assembly of the CTF18-RFC
CC       complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3,
CC       RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn
CC       interacts with DCC1. The CTF18-RFC complex associates with PCNA and
CC       with DNA polymerase POLH. The CTF18-RFC complex does not interact with
CC       the Rad9/Rad1/Hus1 complex. CTF18 interacts with SMC1A and RAD21.
CC       Interacts with DDX11. {ECO:0000250|UniProtKB:Q8WVB6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Associates with chromatin during S
CC       phase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. CTF18
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AK077947; BAC37079.1; -; mRNA.
DR   EMBL; BC024142; AAH24142.1; -; mRNA.
DR   CCDS; CCDS28523.1; -.
DR   RefSeq; NP_663384.2; NM_145409.2.
DR   AlphaFoldDB; Q8BIW9; -.
DR   BioGRID; 229573; 6.
DR   STRING; 10090.ENSMUSP00000043896; -.
DR   iPTMnet; Q8BIW9; -.
DR   PhosphoSitePlus; Q8BIW9; -.
DR   EPD; Q8BIW9; -.
DR   jPOST; Q8BIW9; -.
DR   MaxQB; Q8BIW9; -.
DR   PaxDb; Q8BIW9; -.
DR   PeptideAtlas; Q8BIW9; -.
DR   PRIDE; Q8BIW9; -.
DR   ProteomicsDB; 283977; -.
DR   DNASU; 214901; -.
DR   GeneID; 214901; -.
DR   KEGG; mmu:214901; -.
DR   UCSC; uc008bbk.2; mouse.
DR   CTD; 63922; -.
DR   MGI; MGI:2384887; Chtf18.
DR   eggNOG; KOG1969; Eukaryota.
DR   InParanoid; Q8BIW9; -.
DR   OrthoDB; 307415at2759; -.
DR   PhylomeDB; Q8BIW9; -.
DR   TreeFam; TF314392; -.
DR   Reactome; R-MMU-174411; Polymerase switching on the C-strand of the telomere.
DR   BioGRID-ORCS; 214901; 4 hits in 74 CRISPR screens.
DR   PRO; PR:Q8BIW9; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8BIW9; protein.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0001673; C:male germ cell nucleus; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003689; F:DNA clamp loader activity; ISO:MGI.
DR   GO; GO:0017116; F:single-stranded DNA helicase activity; ISO:MGI.
DR   GO; GO:0007059; P:chromosome segregation; IMP:MGI.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0007281; P:germ cell development; IMP:MGI.
DR   GO; GO:0007140; P:male meiotic nuclear division; IMP:MGI.
DR   GO; GO:0051985; P:negative regulation of chromosome segregation; IMP:MGI.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; ISS:UniProtKB.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IMP:MGI.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell cycle; DNA replication; DNA-binding; Nucleotide-binding;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..969
FT                   /note="Chromosome transmission fidelity protein 18 homolog"
FT                   /id="PRO_0000340082"
FT   REGION          30..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          856..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..878
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         369..376
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         51
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVB6"
FT   MOD_RES         221
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVB6"
FT   CONFLICT        880
FT                   /note="G -> E (in Ref. 2; AAH24142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        885
FT                   /note="A -> V (in Ref. 1; BAC37079)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        898
FT                   /note="K -> T (in Ref. 1; BAC37079)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   969 AA;  108137 MW;  E0269C507AF514BD CRC64;
     MEDYEEDLYG VEDDFQNQFA AELEVLAELE GTRDQAPPGT LQTPASRPPL TFEEAIAGGD
     TVPRPCPAGS PGNVNRNTRK NVRRDQPAPS SPMVKRPRLD VVKKLNFEPD MEELLYPDSP
     PGDITPPPSP EVFPEMLDAG YSDANADKDL MQTLPSPRNR NPVLRRPPIL EDYINVTSTS
     GERAFLVLRA DLIGPGVQNP LLDVHWRGCG QLDLLGVPFA SLKEQVDSKR RQQLLEDAQQ
     LSDTLHSLRS EGEEAVLEGP PAEEPAPGQN TAQHCLWVDE FAPQHYTELL SDDFTNRCLL
     KWLKLWDLVV FGRERPARKP RPGVETTRVG KEATAPGKWK SHEQALEEML EAELDPSQRP
     RQKVALLCGP PGLGKTTLAH VVARHAGYCV VEMNASDDRS PEAFRTRIEA ATQMESVLGV
     GGRPNCLVID EIDGAPTAAI NVLLGILNRK GPQEADQGGT AVAAGGRRRR AEGGLLTRPI
     ICICNDQFTP SLRQLKQQAL LLHVPPTLPS RLVQRLQEIS LQHGMRSDPG ALVALCEKTD
     NDIRACINTL QFLYGRGRRE LSVKAVQTTH VGLKDQRKGL FSVWQEVFQL PRTQRRIVGQ
     DLMLPAHALL LSNGDKGSLT LASQRFYHIL RVTTSAGEHE KVVQGLFDNF LRLRLRDSSL
     STVCCALDWL AFDDLLEQAA HRGQSFQLLC YLPFVPAAFH VLFASSHVPR ITFPSSQQEA
     QTRMSQTRNH IQTLVSGMAP TTRSRATPQA LVLDTLCLLL DVLAPKLRPV STQLYSAHEK
     QQLSCLVGTM LAYSLTYHQE RTPDGQYLYK LEPNVEEVCR FPELPARKPL TYQAKQLIAR
     EIEMEKMRRA EALAWARSGP QVDQGSSGPA SLWTDSGEKG TRQPAPRNHE QRLEHIMKRA
     TVQEQPERDF FGRVVIRKVA VPSREVEAPQ KDADEWRMGV AVGRSEVWFR FNEGVSNAVR
     RSLYIRDLL
 
 
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