ID   CTF18_SCHPO             Reviewed;         960 AA.
AC   Q9USQ1; Q9UTY7;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Chromosome transmission fidelity protein 18;
GN   Name=ctf18; Synonyms=chl12; ORFNames=SPBC902.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 812-840, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
RN   [3]
RP   FUNCTION, AND IDENTIFICATION IN THE RFC COMPLEX.
RX   PubMed=15226378; DOI=10.1242/jcs.01231;
RA   Petronczki M., Chwalla B., Siomos M.F., Yokobayashi S., Helmhart W.,
RA   Deutschbauer A.M., Davis R.W., Watanabe Y., Nasmyth K.;
RT   "Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8,
RT   the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is
RT   essential for chromatid disjunction during meiosis II.";
RL   J. Cell Sci. 117:3547-3559(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=16040599; DOI=10.1093/nar/gki728;
RA   Kim J., Robertson K., Mylonas K.J.L., Gray F.C., Charapitsa I.,
RA   MacNeill S.A.;
RT   "Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence
RT   of fully functional RFC in fission yeast.";
RL   Nucleic Acids Res. 33:4078-4089(2005).
CC   -!- FUNCTION: Essential for the fidelity of chromosome transmission.
CC       Required for the DNA replication block checkpoint. Replication factor C
CC       (RFC) complex has an essential but redundant activity in sister
CC       chromatid cohesion establishment. Acts as a PCNA loader, loading PCNA
CC       onto primed templates. An RFC-like complex (ctf18-RFC) is formed where
CC       ctf18 replaces rfc1 in the RFC complex along with the association of
CC       dcc1 and ctf8. This complex is required for efficient establishment of
CC       chromosome cohesion during S-phase. {ECO:0000269|PubMed:15226378,
CC       ECO:0000269|PubMed:16040599}.
CC   -!- SUBUNIT: Component of the ctf18-RFC complex which consists of ctf18,
CC       ctf8, dcc1, rfc2, rfc3, rfc4 and rfc5. {ECO:0000305|PubMed:15226378}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10759889}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. CTF18
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CU329671; CAB62096.1; -; Genomic_DNA.
DR   EMBL; AB027926; BAA87230.1; -; Genomic_DNA.
DR   PIR; T50383; T50383.
DR   RefSeq; NP_595200.1; NM_001021106.2.
DR   AlphaFoldDB; Q9USQ1; -.
DR   BioGRID; 277784; 60.
DR   STRING; 4896.SPBC902.02c.1; -.
DR   iPTMnet; Q9USQ1; -.
DR   MaxQB; Q9USQ1; -.
DR   PaxDb; Q9USQ1; -.
DR   PRIDE; Q9USQ1; -.
DR   EnsemblFungi; SPBC902.02c.1; SPBC902.02c.1:pep; SPBC902.02c.
DR   GeneID; 2541270; -.
DR   KEGG; spo:SPBC902.02c; -.
DR   PomBase; SPBC902.02c; ctf18.
DR   VEuPathDB; FungiDB:SPBC902.02c; -.
DR   eggNOG; KOG1969; Eukaryota.
DR   HOGENOM; CLU_004894_3_1_1; -.
DR   InParanoid; Q9USQ1; -.
DR   OMA; SIIHFHY; -.
DR   PhylomeDB; Q9USQ1; -.
DR   PRO; PR:Q9USQ1; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0000785; C:chromatin; IDA:PomBase.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; IPI:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0043596; C:nuclear replication fork; IC:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; NAS:PomBase.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045005; P:DNA-templated DNA replication maintenance of fidelity; IMP:PomBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell cycle; DNA replication; DNA-binding; Nucleotide-binding;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..960
FT                   /note="Chromosome transmission fidelity protein 18"
FT                   /id="PRO_0000239058"
FT   REGION          56..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         423..430
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        812..840
FT                   /note="HAINILNHYNLRFQQLPVGDGNYVYRLEP -> PLEMATMCIGLSRKFQYFY
FT                   FFLVIANVDR (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   960 AA;  108651 MW;  6A4ACAEB5B74E8BC CRC64;
     MDSIPNEDDL EKLLVAEQNV PYGKNYESFE DEENYLLELR NANALENLEH RSIPNDLFHS
     SQPVGSPTRN GDDIPSTLDL YSSDNAAIDT DISEDETINQ RHAPQTDYRY PNTSANPKMG
     LEESMDIDMP SIDLDISNAA AFPRDSNLLF RNYNSHTKTS EKGSPVNFEK ENQDSNVLFS
     TGRTSVLHID AEQSQTNNTV TPLKDDALSL FSFENDVNGA VNDNSLDQKL SASKNSQRVS
     LPFFSKIELD EGSSFSGPKI SARTSSGKII YFPKKKNRHS DGLLLQPKRL ADEISQVNEI
     GKDFNQDLLN SVRIWSENFL IVSKEKSVAL KTEKLDSLQI TNCTTKPQSQ KLWVDTYRPQ
     LFRDLLGDER VHRAAMHWIK AWDPCVFGKS RLQPSKSMRF NPRFTNITSD SDRPDKRIMM
     LTGLAGAGKT TLAHVIAHQA GYKVLEINAS DDRTAHTVHE KVSSAISNHS ALSSQPTCVI
     VDEIDGGDPA FVRALLSLLE SDEKATEYSQ AGNSKKKKKF KKLCRPIICI CNDLYTPALR
     PLRPYAQIIY FRPPPQASLV GRLRTICRNE NIAVDSRSLT LLTDIYNSDI RSCINSLQLL
     SLNNKRIDSE TIKLLQPKSN SFSTSSLIQS LFLQLDNKQI RAIEASQPTY SHLDALLARI
     DGANDSESVL MNCFHTYLDL PFTDSLLSKP ALTSEWLYFF DQLHSQCYKG NYELWRYIPY
     SIIHFHYLYA TPEKCRLPHP PRSDLEALKL YRTRKEILDS FISTLNAYEN QMHGERSILL
     ELIRTILITI NPTLKQKEDS MPRSALPSKI EHAINILNHY NLRFQQLPVG DGNYVYRLEP
     PLDELVWDAP TSSYSVRQML SQELLKKRLA DIKKQTLTDN PTSSNSSRKR KDFNSGKAIK
     RDFFGRIISE PKSEAVTSNN AALNTGDHPV SIKHAINIKF HDGFSNAVRK PISLNEILNF