ID   CTF1_MOUSE              Reviewed;         203 AA.
AC   Q60753;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Cardiotrophin-1;
DE            Short=CT-1;
GN   Name=Ctf1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7862649; DOI=10.1073/pnas.92.4.1142;
RA   Pennica D., King K.L., Shaw K.J., Luis E., Rullamas J., Luoh S.-M.,
RA   Darbonne W.C., Knutzon D.S., Yen R., Chien K.R., Baker J.B., Wood W.I.;
RT   "Expression cloning of cardiotrophin 1, a cytokine that induces cardiac
RT   myocyte hypertrophy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:1142-1146(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Induces cardiac myocyte hypertrophy in vitro. Binds to and
CC       activates the ILST/gp130 receptor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, liver,
CC       lung and kidney. Lower levels in testis and brain. No expression in
CC       spleen.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; U18366; AAC52173.1; -; mRNA.
DR   EMBL; BC024381; AAH24381.1; -; mRNA.
DR   CCDS; CCDS21875.1; -.
DR   PIR; I49153; I49153.
DR   RefSeq; NP_031821.1; NM_007795.1.
DR   AlphaFoldDB; Q60753; -.
DR   SMR; Q60753; -.
DR   DIP; DIP-5773N; -.
DR   STRING; 10090.ENSMUSP00000049161; -.
DR   PhosphoSitePlus; Q60753; -.
DR   MaxQB; Q60753; -.
DR   PaxDb; Q60753; -.
DR   PRIDE; Q60753; -.
DR   ProteomicsDB; 284141; -.
DR   Antibodypedia; 27491; 502 antibodies from 32 providers.
DR   DNASU; 13019; -.
DR   Ensembl; ENSMUST00000047393; ENSMUSP00000049161; ENSMUSG00000042340.
DR   GeneID; 13019; -.
DR   KEGG; mmu:13019; -.
DR   UCSC; uc009jwm.2; mouse.
DR   CTD; 1489; -.
DR   MGI; MGI:105115; Ctf1.
DR   VEuPathDB; HostDB:ENSMUSG00000042340; -.
DR   eggNOG; ENOG502S5Z6; Eukaryota.
DR   GeneTree; ENSGT00510000048856; -.
DR   HOGENOM; CLU_117233_0_0_1; -.
DR   InParanoid; Q60753; -.
DR   OMA; GLYREWV; -.
DR   OrthoDB; 1444458at2759; -.
DR   PhylomeDB; Q60753; -.
DR   TreeFam; TF333266; -.
DR   Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions.
DR   BioGRID-ORCS; 13019; 4 hits in 73 CRISPR screens.
DR   PRO; PR:Q60753; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q60753; protein.
DR   Bgee; ENSMUSG00000042340; Expressed in vestibular membrane of cochlear duct and 178 other tissues.
DR   ExpressionAtlas; Q60753; baseline and differential.
DR   Genevisible; Q60753; MM.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; ISO:MGI.
DR   GO; GO:0005146; F:leukemia inhibitory factor receptor binding; ISO:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0048861; P:leukemia inhibitory factor signaling pathway; ISO:MGI.
DR   GO; GO:0007399; P:nervous system development; ISO:MGI.
DR   GO; GO:0048666; P:neuron development; IGI:MGI.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:MGI.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR010681; PRF/CT.
DR   PANTHER; PTHR21353; PTHR21353; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Reference proteome; Secreted.
FT   CHAIN           1..203
FT                   /note="Cardiotrophin-1"
FT                   /id="PRO_0000058763"
SQ   SEQUENCE   203 AA;  21509 MW;  8B3D414A0B3B232F CRC64;
     MSQREGSLED HQTDSSISFL PHLEAKIRQT HNLARLLTKY AEQLLEEYVQ QQGEPFGLPG
     FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSVLPAL LDAVRRRQAE LNPRAPRLLR
     SLEDAARQVR ALGAAVETVL AALGAAARGP GPEPVTVATL FTANSTAGIF SAKVLGFHVC
     GLYGEWVSRT EGDLGQLVPG GVA