ID   CTF1_RAT                Reviewed;         203 AA.
AC   Q63086;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Cardiotrophin-1;
DE            Short=CT-1;
GN   Name=Ctf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Heart;
RX   PubMed=8604995; DOI=10.1006/bbrc.1996.0241;
RA   Ishikawa M., Saito Y., Miyamoto Y., Kuwahara K., Ogawa E., Nakagawa O.,
RA   Harada M., Masuda I., Nakao K.;
RT   "cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1
RT   gene in ventricle of genetically hypertensive rats.";
RL   Biochem. Biophys. Res. Commun. 219:377-381(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Induces cardiac myocyte hypertrophy in vitro. Binds to and
CC       activates the ILST/gp130 receptor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the ventricle and atrium of adult
CC       rats. Also detected in the lung, kidney, liver, skeletal muscle,
CC       stomach and urinary bladder. Not detected in brain, colon, testis,
CC       spleen or thymus. Overexpressed in the ventricles in the case of
CC       hypertension and hypertrophy.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D78591; BAA11427.1; -; mRNA.
DR   EMBL; BC072690; AAH72690.1; -; mRNA.
DR   PIR; JC4645; JC4645.
DR   RefSeq; NP_058825.1; NM_017129.1.
DR   AlphaFoldDB; Q63086; -.
DR   SMR; Q63086; -.
DR   STRING; 10116.ENSRNOP00000025646; -.
DR   PhosphoSitePlus; Q63086; -.
DR   jPOST; Q63086; -.
DR   PaxDb; Q63086; -.
DR   GeneID; 29201; -.
DR   KEGG; rno:29201; -.
DR   UCSC; RGD:2442; rat.
DR   CTD; 1489; -.
DR   RGD; 2442; Ctf1.
DR   VEuPathDB; HostDB:ENSRNOG00000018962; -.
DR   eggNOG; ENOG502S5Z6; Eukaryota.
DR   HOGENOM; CLU_117233_0_0_1; -.
DR   InParanoid; Q63086; -.
DR   OMA; GLYREWV; -.
DR   OrthoDB; 1444458at2759; -.
DR   PhylomeDB; Q63086; -.
DR   TreeFam; TF333266; -.
DR   Reactome; R-RNO-6788467; IL-6-type cytokine receptor ligand interactions.
DR   PRO; PR:Q63086; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000018962; Expressed in kidney and 19 other tissues.
DR   Genevisible; Q63086; RN.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IMP:RGD.
DR   GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IMP:RGD.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0048861; P:leukemia inhibitory factor signaling pathway; IMP:RGD.
DR   GO; GO:0007399; P:nervous system development; IDA:RGD.
DR   GO; GO:0048666; P:neuron development; ISO:RGD.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001581; Leukemia_IF/oncostatin.
DR   InterPro; IPR010681; PRF/CT.
DR   PANTHER; PTHR21353; PTHR21353; 1.
DR   Pfam; PF01291; LIF_OSM; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Reference proteome; Secreted.
FT   CHAIN           1..203
FT                   /note="Cardiotrophin-1"
FT                   /id="PRO_0000058764"
SQ   SEQUENCE   203 AA;  21439 MW;  DF8B921A2FA1C832 CRC64;
     MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ QQGEPFGLPG
     FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL LDAVRRRQAE LNPRAPRLLR
     SLEDAARQVR ALGAAVETVL AALGAAARGP VPEPVATSAL FTSNSAAGVF SAKVLGLHVC
     GLYGEWVSRT EGDLGQLVPG GVA