ID   CTF2_MOUSE              Reviewed;         204 AA.
AC   P83714;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   21-NOV-2003, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Cardiotrophin-2;
DE            Short=CT-2;
DE   AltName: Full=Neuropoietin;
DE            Short=Np;
DE   Flags: Precursor;
GN   Name=Ctf2; Synonyms=Gm494;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hasegawa M., Habu K., Adachi Y., Natori O.;
RT   "Cardiotrophin-2 increases the platelet counts with splenomegaly in vivo.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   STRAIN=BALB/cJ; TISSUE=Brain;
RX   PubMed=15051883; DOI=10.1073/pnas.0306178101;
RA   Derouet D., Rousseau F., Alfonsi F., Froger J., Hermann J., Barbier F.,
RA   Perret D., Diveu C., Guillet C., Preisser L., Dumont A., Barbado M.,
RA   Morel A., DeLapeyriere O., Gascan H., Chevalier S.;
RT   "Neuropoietin, a new IL-6-related cytokine signaling through the ciliary
RT   neurotrophic factor receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:4827-4832(2004).
CC   -!- FUNCTION: Increases the platelet count associated with splenomegaly.
CC       May have an important role in neuronal precursor development and
CC       maturation.
CC   -!- SUBUNIT: Binds to tripartite CNTF receptor complex consisting of CNTF
CC       alpha chain, LIFR and IL6ST (in vitro).
CC   -!- INTERACTION:
CC       P83714; Q99523: SORT1; Xeno; NbExp=2; IntAct=EBI-25298303, EBI-1057058;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Not detected in adult tissues.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryonic life, with a dramatic peak
CC       at day 11 of gestation. At 10 dpc, it is prominently expressed in cells
CC       scattered throughout all neuroepithelia, it is also detectable in
CC       cranial and dorsal root sensory ganglia, and spinal cord. At 14 dpc,
CC       outside the nervous system, it is detectable in vibrissae, dermis, and
CC       to a lesser extent in skeletal muscle, lung, and kidney.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB125661; BAD01485.1; -; mRNA.
DR   EMBL; AY363390; AAR17733.1; -; mRNA.
DR   CCDS; CCDS21876.1; -.
DR   RefSeq; NP_942155.1; NM_198858.1.
DR   AlphaFoldDB; P83714; -.
DR   SMR; P83714; -.
DR   BioGRID; 232625; 3.
DR   IntAct; P83714; 1.
DR   STRING; 10090.ENSMUSP00000075459; -.
DR   GlyGen; P83714; 1 site.
DR   PaxDb; P83714; -.
DR   PRIDE; P83714; -.
DR   DNASU; 244218; -.
DR   Ensembl; ENSMUST00000076091; ENSMUSP00000075459; ENSMUSG00000060034.
DR   GeneID; 244218; -.
DR   KEGG; mmu:244218; -.
DR   UCSC; uc009jwn.1; mouse.
DR   CTD; 244218; -.
DR   MGI; MGI:2684607; Ctf2.
DR   VEuPathDB; HostDB:ENSMUSG00000060034; -.
DR   eggNOG; ENOG502S1XV; Eukaryota.
DR   GeneTree; ENSGT00510000048856; -.
DR   HOGENOM; CLU_117935_0_0_1; -.
DR   InParanoid; P83714; -.
DR   OMA; YMQKNTS; -.
DR   OrthoDB; 1375676at2759; -.
DR   PhylomeDB; P83714; -.
DR   TreeFam; TF333266; -.
DR   BioGRID-ORCS; 244218; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Ctf2; mouse.
DR   PRO; PR:P83714; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P83714; protein.
DR   Bgee; ENSMUSG00000060034; Expressed in primary oocyte and 44 other tissues.
DR   ExpressionAtlas; P83714; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IPI:MGI.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IPI:MGI.
DR   GO; GO:0008283; P:cell population proliferation; IGI:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007405; P:neuroblast proliferation; IGI:MGI.
DR   GO; GO:0002052; P:positive regulation of neuroblast proliferation; IGI:MGI.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR010681; PRF/CT.
DR   PANTHER; PTHR21353; PTHR21353; 1.
DR   Pfam; PF06875; PRF; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Cytokine; Developmental protein; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..204
FT                   /note="Cardiotrophin-2"
FT                   /id="PRO_0000015614"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   204 AA;  22000 MW;  B05566C1E7C3D9C0 CRC64;
     MYCLLATPLC LLSLLLPPLS PAAPISPSEP IGQAYSLALY MQKNTSALLQ TYLQHQGSPF
     SDPGFSAPEL QLSTLPSAAV SFKTWHAMED AERLSRAQGA FLALTQHLQL VGDDQSYLNP
     GSPILLAQLG AARLRAQGLL GNMAAIMTAL GLPIPPEEDT LGFVPFGASA FERKCRGYIV
     TREYGHWTDR AVRDLALLKA KYSA