ID   CTF2_PANTR              Reviewed;         203 AA.
AC   Q6R2R2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Cardiotrophin-2;
DE            Short=CT-2;
DE   AltName: Full=Neuropoietin;
DE            Short=Np;
DE   Flags: Precursor;
GN   Name=CTF2;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15051883; DOI=10.1073/pnas.0306178101;
RA   Derouet D., Rousseau F., Alfonsi F., Froger J., Hermann J., Barbier F.,
RA   Perret D., Diveu C., Guillet C., Preisser L., Dumont A., Barbado M.,
RA   Morel A., DeLapeyriere O., Gascan H., Chevalier S.;
RT   "Neuropoietin, a new IL-6-related cytokine signaling through the ciliary
RT   neurotrophic factor receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:4827-4832(2004).
CC   -!- FUNCTION: May have an important role in neuronal precursor development
CC       and maturation.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; AY518207; AAS66750.1; -; Genomic_DNA.
DR   RefSeq; NP_001009112.1; NM_001009112.1.
DR   AlphaFoldDB; Q6R2R2; -.
DR   SMR; Q6R2R2; -.
DR   STRING; 9598.ENSPTRP00000054644; -.
DR   PaxDb; Q6R2R2; -.
DR   GeneID; 467956; -.
DR   KEGG; ptr:467956; -.
DR   CTD; 244218; -.
DR   eggNOG; KOG1633; Eukaryota.
DR   InParanoid; Q6R2R2; -.
DR   OrthoDB; 1375676at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR010681; PRF/CT.
DR   PANTHER; PTHR21353; PTHR21353; 1.
DR   Pfam; PF06875; PRF; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   3: Inferred from homology;
KW   Cytokine; Developmental protein; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..203
FT                   /note="Cardiotrophin-2"
FT                   /id="PRO_0000015615"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   203 AA;  21848 MW;  858B742EFB28935B CRC64;
     MSCSLARLCL LTLLSPPLSS AASISPAEPI SQAYSLALYM QKNTSALLRT YLQYQGSPLS
     DPGFSAPELQ LSSLPPATAF FKTWHALDDG EWLSLAQRAF LALTQHLQLV EDDQSDLNPG
     SPILLAQLGA ARLRAQGLLG NMAAITTALG LPIPPEEDTL GLAAFGASAF ERKCRGYVVT
     REYGHWTDRA VRDLALLKAK YSA