CTF8_BOVIN
ID CTF8_BOVIN Reviewed; 121 AA.
AC P0CG11; A8E4M1; P0C6S9;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Chromosome transmission fidelity protein 8 homolog {ECO:0000250|UniProtKB:P0CG13};
GN Name=CHTF8 {ECO:0000250|UniProtKB:P0CG13}; Synonyms=CTF8;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
CC -!- FUNCTION: Chromosome cohesion factor involved in sister chromatid
CC cohesion and fidelity of chromosome transmission. Component of one of
CC the cell nuclear antigen loader complexes, CTF18-replication factor C
CC (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and
CC RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs
CC and has weak ATPase activity that is stimulated the presence of primed
CC DNA, replication protein A (RPA) and proliferating cell nuclear antigen
CC (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of
CC PCNA onto primed and gapped DNA. It also interacts with and stimulates
CC POLH, which is suggestive of a protein network that coordinates DNA
CC repair, recombination and chromosome cohesion reactions with
CC replication fork progression (By similarity).
CC {ECO:0000250|UniProtKB:P0CG13}.
CC -!- SUBUNIT: Component of the CTF18-RFC complex, which consists of CTF18,
CC CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not
CC interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex
CC interacts with POLH. CTF18/CTF8/DSCC1 associate with PCNA. CTF8 exists
CC as a dimer with DSCC1 (By similarity). {ECO:0000250|UniProtKB:P0CG13}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0CG13}.
CC Note=Associates with chromatin during S phase.
CC {ECO:0000250|UniProtKB:P0CG13}.
CC -!- SIMILARITY: Belongs to the CTF8 family. {ECO:0000305}.
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DR EMBL; AAFC03016849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001108441.1; NM_001114969.2.
DR RefSeq; XP_005218793.1; XM_005218736.3.
DR AlphaFoldDB; P0CG11; -.
DR STRING; 9913.ENSBTAP00000002226; -.
DR PaxDb; P0CG11; -.
DR PRIDE; P0CG11; -.
DR Ensembl; ENSBTAT00000002226; ENSBTAP00000002226; ENSBTAG00000001698.
DR GeneID; 618186; -.
DR KEGG; bta:618186; -.
DR CTD; 54921; -.
DR VEuPathDB; HostDB:ENSBTAG00000001698; -.
DR eggNOG; ENOG502S2DB; Eukaryota.
DR GeneTree; ENSGT00650000093476; -.
DR HOGENOM; CLU_066293_3_0_1; -.
DR OrthoDB; 639828at2759; -.
DR TreeFam; TF314676; -.
DR Reactome; R-BTA-174411; Polymerase switching on the C-strand of the telomere.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000001698; Expressed in myometrium and 104 other tissues.
DR ExpressionAtlas; P0CG11; baseline.
DR GO; GO:0031390; C:Ctf18 RFC-like complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:GOC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0007064; P:mitotic sister chromatid cohesion; IEA:InterPro.
DR GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; ISS:UniProtKB.
DR InterPro; IPR018607; Ctf8.
DR Pfam; PF09696; Ctf8; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA replication; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..121
FT /note="Chromosome transmission fidelity protein 8 homolog"
FT /id="PRO_0000327252"
SQ SEQUENCE 121 AA; 13161 MW; 571B6F7F6D029198 CRC64;
MVQIVISSAG AGGLAEWVLM ELQGEIEARH STGLAGNLLG DLHYTTEGIP VLIVGHHILY
GKIIHLEKPF AVLVKHTPGE QDCDELGCES GTRYLVTALI KNKILFKTRP KPIITNVPKK
V