ID   CTF8_HUMAN              Reviewed;         121 AA.
AC   P0CG13; A8MYX8; Q71E72; Q8NDH8; Q8WV66; Q9NX73;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Chromosome transmission fidelity protein 8 homolog {ECO:0000305};
DE            Short=hCTF8 {ECO:0000303|PubMed:12766176};
GN   Name=CHTF8 {ECO:0000312|HGNC:HGNC:24353}; Synonyms=CTF8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION IN THE CTF18-RFC COMPLEX, AND SUBCELLULAR LOCATION.
RX   PubMed=12766176; DOI=10.1074/jbc.m211591200;
RA   Merkle C.J., Karnitz L.M., Henry-Sanchez J.T., Chen J.;
RT   "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs
RT   of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion
RT   establishment.";
RL   J. Biol. Chem. 278:30051-30056(2003).
RN   [4]
RP   FUNCTION, IDENTIFICATION IN THE CTF18-RFC COMPLEX, INTERACTION WITH DSCC1,
RP   AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=12930902; DOI=10.1073/pnas.1434308100;
RA   Bermudez V.P., Maniwa Y., Tappin I., Ozato K., Yokomori K., Hurwitz J.;
RT   "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for
RT   sister chromatid cohesion loads proliferating cell nuclear antigen onto
RT   DNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10237-10242(2003).
RN   [5]
RP   FUNCTION OF THE CTF18-RFC COMPLEX, INTERACTION OF THE CTF18-RFC COMPLEX
RP   WITH POLH, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17545166; DOI=10.1074/jbc.m610102200;
RA   Shiomi Y., Masutani C., Hanaoka F., Kimura H., Tsurimoto T.;
RT   "A second proliferating cell nuclear antigen loader complex, Ctf18-
RT   replication factor C, stimulates DNA polymerase eta activity.";
RL   J. Biol. Chem. 282:20906-20914(2007).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: Chromosome cohesion factor involved in sister chromatid
CC       cohesion and fidelity of chromosome transmission. Component of one of
CC       the cell nuclear antigen loader complexes, CTF18-replication factor C
CC       (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and
CC       RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs
CC       and has weak ATPase activity that is stimulated the presence of primed
CC       DNA, replication protein A (RPA) and proliferating cell nuclear antigen
CC       (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of
CC       PCNA onto primed and gapped DNA. It also interacts with and stimulates
CC       POLH, which is suggestive of a protein network that coordinates DNA
CC       repair, recombination and chromosome cohesion reactions with
CC       replication fork progression. {ECO:0000269|PubMed:12930902,
CC       ECO:0000269|PubMed:17545166}.
CC   -!- SUBUNIT: Component of the CTF18-RFC complex, which consists of CTF18,
CC       CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not
CC       interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex
CC       interacts with POLH. CTF18/CTF8/DSCC1 associate with PCNA. CTF8 exists
CC       as a dimer with DSCC1. {ECO:0000269|PubMed:12766176,
CC       ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12766176}.
CC       Note=Associates with chromatin during S phase.
CC       {ECO:0000269|PubMed:12766176}.
CC   -!- SIMILARITY: Belongs to the CTF8 family. {ECO:0000305}.
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DR   EMBL; AC009027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC018700; AAH18700.4; -; mRNA.
DR   CCDS; CCDS42185.1; -.
DR   RefSeq; NP_001034779.1; NM_001039690.3.
DR   RefSeq; NP_001035236.1; NM_001040146.3.
DR   RefSeq; XP_016878859.1; XM_017023370.1.
DR   AlphaFoldDB; P0CG13; -.
DR   BioGRID; 120262; 29.
DR   CORUM; P0CG13; -.
DR   IntAct; P0CG13; 7.
DR   STRING; 9606.ENSP00000408367; -.
DR   iPTMnet; P0CG13; -.
DR   PhosphoSitePlus; P0CG13; -.
DR   BioMuta; CHTF8; -.
DR   DMDM; 298351632; -.
DR   EPD; P0CG13; -.
DR   jPOST; P0CG13; -.
DR   MassIVE; P0CG13; -.
DR   MaxQB; P0CG13; -.
DR   PaxDb; P0CG13; -.
DR   PeptideAtlas; P0CG13; -.
DR   PRIDE; P0CG13; -.
DR   Antibodypedia; 66354; 15 antibodies from 7 providers.
DR   DNASU; 54921; -.
DR   Ensembl; ENST00000398235.6; ENSP00000381290.2; ENSG00000168802.14.
DR   Ensembl; ENST00000448552.7; ENSP00000408367.3; ENSG00000168802.14.
DR   GeneID; 54921; -.
DR   KEGG; hsa:54921; -.
DR   MANE-Select; ENST00000448552.7; ENSP00000408367.3; NM_001039690.5; NP_001034779.1.
DR   UCSC; uc002ewn.3; human.
DR   CTD; 54921; -.
DR   GeneCards; CHTF8; -.
DR   HGNC; HGNC:24353; CHTF8.
DR   HPA; ENSG00000168802; Low tissue specificity.
DR   MIM; 613202; gene.
DR   neXtProt; NX_P0CG13; -.
DR   OpenTargets; ENSG00000168802; -.
DR   PharmGKB; PA164717934; -.
DR   VEuPathDB; HostDB:ENSG00000168802; -.
DR   eggNOG; ENOG502S2DB; Eukaryota.
DR   GeneTree; ENSGT00400000025006; -.
DR   HOGENOM; CLU_066293_3_0_1; -.
DR   OMA; IGIHVLH; -.
DR   OrthoDB; 639828at2759; -.
DR   TreeFam; TF314676; -.
DR   PathwayCommons; P0CG13; -.
DR   Reactome; R-HSA-174411; Polymerase switching on the C-strand of the telomere.
DR   SignaLink; P0CG13; -.
DR   BioGRID-ORCS; 54921; 367 hits in 1088 CRISPR screens.
DR   ChiTaRS; CHTF8; human.
DR   GeneWiki; CTF8; -.
DR   GenomeRNAi; 54921; -.
DR   Pharos; P0CG13; Tbio.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000168802; Expressed in granulocyte and 97 other tissues.
DR   ExpressionAtlas; P0CG13; baseline and differential.
DR   Genevisible; P0CG13; HS.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032508; P:DNA duplex unwinding; IEA:GOC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; IEA:InterPro.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; IDA:UniProtKB.
DR   InterPro; IPR018607; Ctf8.
DR   Pfam; PF09696; Ctf8; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Chromosome transmission fidelity protein 8 homolog"
FT                   /id="PRO_0000327253"
SQ   SEQUENCE   121 AA;  13314 MW;  17F58496A479DA3F CRC64;
     MVQIVISSAR AGGLAEWVLM ELQGEIEARY STGLAGNLLG DLHYTTEGIP VLIVGHHILY
     GKIIHLEKPF AVLVKHTPGD QDCDELGRET GTRYLVTALI KDKILFKTRP KPIITSVPKK
     V