ID   CTF8_RAT                Reviewed;         121 AA.
AC   P0C6T1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Chromosome transmission fidelity protein 8 homolog {ECO:0000250|UniProtKB:P0CG13};
GN   Name=Chtf8 {ECO:0000312|RGD:1306894}; Synonyms=Ctf8;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
CC   -!- FUNCTION: Chromosome cohesion factor involved in sister chromatid
CC       cohesion and fidelity of chromosome transmission. Component of one of
CC       the cell nuclear antigen loader complexes, CTF18-replication factor C
CC       (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and
CC       RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs
CC       and has weak ATPase activity that is stimulated the presence of primed
CC       DNA, replication protein A (RPA) and proliferating cell nuclear antigen
CC       (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of
CC       PCNA onto primed and gapped DNA. It also interacts with and stimulates
CC       POLH, which is suggestive of a protein network that coordinates DNA
CC       repair, recombination and chromosome cohesion reactions with
CC       replication fork progression (By similarity).
CC       {ECO:0000250|UniProtKB:P0CG13}.
CC   -!- SUBUNIT: Component of the CTF18-RFC complex, which consists of CTF18,
CC       CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not
CC       interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex
CC       interacts with POLH. CTF18/CTF8/DSCC1 associate with PCNA. CTF8 exists
CC       as a dimer with DSCC1 (By similarity). {ECO:0000250|UniProtKB:P0CG13}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0CG13}.
CC       Note=Associates with chromatin during S phase.
CC       {ECO:0000250|UniProtKB:P0CG13}.
CC   -!- SIMILARITY: Belongs to the CTF8 family. {ECO:0000305}.
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DR   EMBL; AABR03113443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001181880.1; NM_001194951.1.
DR   AlphaFoldDB; P0C6T1; -.
DR   BioGRID; 265075; 1.
DR   STRING; 10116.ENSRNOP00000063969; -.
DR   PhosphoSitePlus; P0C6T1; -.
DR   GeneID; 364996; -.
DR   KEGG; rno:364996; -.
DR   UCSC; RGD:1306894; rat.
DR   CTD; 54921; -.
DR   RGD; 1306894; Chtf8.
DR   VEuPathDB; HostDB:ENSRNOG00000047246; -.
DR   HOGENOM; CLU_066293_3_0_1; -.
DR   OMA; IGIHVLH; -.
DR   OrthoDB; 1551444at2759; -.
DR   PhylomeDB; P0C6T1; -.
DR   TreeFam; TF314676; -.
DR   Reactome; R-RNO-174411; Polymerase switching on the C-strand of the telomere.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000047246; Expressed in thymus and 19 other tissues.
DR   Genevisible; P0C6T1; RN.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032508; P:DNA duplex unwinding; IEA:GOC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; IEA:InterPro.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; ISS:UniProtKB.
DR   InterPro; IPR018607; Ctf8.
DR   Pfam; PF09696; Ctf8; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Chromosome transmission fidelity protein 8 homolog"
FT                   /id="PRO_0000327255"
SQ   SEQUENCE   121 AA;  13328 MW;  0F55D30631C0091C CRC64;
     MVQIVISSTG AEGLAEWVLM ELQGEIEARY STGLAGNLLG DLHYTTEGIP VLIVGHHILY
     GKIIHLEKPF AVLVKHTPGK QDCDELGRET GTQYLVTALI KNKILFKTRP KPIITNVPKK
     V