ID   CTF8_SCHPO              Reviewed;         109 AA.
AC   Q65ZA6;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Chromosome transmission fidelity protein 8;
GN   Name=ctf8; ORFNames=SPAC19D5.11c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, AND IDENTIFICATION IN THE RFC COMPLEX.
RX   PubMed=15226378; DOI=10.1242/jcs.01231;
RA   Petronczki M., Chwalla B., Siomos M.F., Yokobayashi S., Helmhart W.,
RA   Deutschbauer A.M., Davis R.W., Watanabe Y., Nasmyth K.;
RT   "Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8,
RT   the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is
RT   essential for chromatid disjunction during meiosis II.";
RL   J. Cell Sci. 117:3547-3559(2004).
CC   -!- FUNCTION: Essential for the fidelity of chromosome transmission.
CC       Required for the DNA replication block checkpoint. Replication factor C
CC       (RFC) complex has an essential but redundant activity in sister
CC       chromatid cohesion establishment. An RFC-like complex (ctf18-RFC) is
CC       formed where ctf18 replaces rfc1 in the RFC complex along with the
CC       association of dcc1 and ctf8. This complex is required for efficient
CC       establishment of chromosome cohesion during S-phase. Acts as a PCNA
CC       loader, loading PCNA onto primed templates.
CC       {ECO:0000269|PubMed:15226378}.
CC   -!- SUBUNIT: Component of the ctf18-RFC complex which consists of ctf18,
CC       ctf8, dcc1, rfc2, rfc3, rfc4 and rfc5. {ECO:0000305|PubMed:15226378}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTF8 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAH25546.1; -; Genomic_DNA.
DR   RefSeq; NP_001018293.1; NM_001020333.2.
DR   AlphaFoldDB; Q65ZA6; -.
DR   SMR; Q65ZA6; -.
DR   BioGRID; 280632; 2.
DR   STRING; 4896.SPAC19D5.11c.1; -.
DR   MaxQB; Q65ZA6; -.
DR   PaxDb; Q65ZA6; -.
DR   EnsemblFungi; SPAC19D5.11c.1; SPAC19D5.11c.1:pep; SPAC19D5.11c.
DR   GeneID; 3361556; -.
DR   KEGG; spo:SPAC19D5.11c; -.
DR   PomBase; SPAC19D5.11c; ctf8.
DR   VEuPathDB; FungiDB:SPAC19D5.11c; -.
DR   HOGENOM; CLU_2238175_0_0_1; -.
DR   InParanoid; Q65ZA6; -.
DR   OMA; GNQCMEG; -.
DR   PRO; PR:Q65ZA6; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; IC:PomBase.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; IC:PomBase.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; ISO:PomBase.
DR   InterPro; IPR018607; Ctf8.
DR   Pfam; PF09696; Ctf8; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..109
FT                   /note="Chromosome transmission fidelity protein 8"
FT                   /id="PRO_0000239056"
SQ   SEQUENCE   109 AA;  12365 MW;  6DAC16D7D8E1B952 CRC64;
     MSEIRLIRAI NDELYLVEVQ ATLERKADSL HIGDLKIIKE KNSEKKKATL TVGNQYMEGV
     VESLKKPLAV LQKTNADPVD VYSSPSHELK CCSIIRERIR FSSRPLPTK