ID   CTFA_CONCB              Reviewed;          35 AA.
AC   B2CS62;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Ca15a;
DE   Flags: Fragment;
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-30, AND HYDROXYLATION AT PRO-8.
RC   TISSUE=Venom;
RX   PubMed=18304695; DOI=10.1016/j.peptides.2008.01.007;
RA   Peng C., Liu L., Shao X.X., Chi C.-W., Wang C.G.;
RT   "Identification of a novel class of conotoxins defined as V-conotoxins with
RT   a unique cysteine pattern and signal peptide sequence.";
RL   Peptides 29:985-991(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-35.
RC   TISSUE=Venom duct;
RA   Liu L., Wu X.C., Wang C.G., Chi C.-W.;
RT   "New V-superfamily conotoxin Ca15a from Conus caracteristicus.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C).
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
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DR   EMBL; EU547208; ACB38369.1; -; mRNA.
DR   AlphaFoldDB; B2CS62; -.
DR   ConoServer; 2825; Ca15a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Secreted; Toxin.
FT   PEPTIDE         1..>35
FT                   /note="Conotoxin Ca15a"
FT                   /id="PRO_0000345114"
FT   MOD_RES         8
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:18304695"
FT   CONFLICT        17
FT                   /note="R -> N (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        21
FT                   /note="Missing (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25..28
FT                   /note="TRPL -> GNPK (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         35
SQ   SEQUENCE   35 AA;  4114 MW;  795203A9E64FDA39 CRC64;
     CRVENKCPHT VCCDRSRCSC KLIRTRPLMY HVCVC