CTG1B_HUMAN
ID CTG1B_HUMAN Reviewed; 180 AA.
AC P78358; A1L417; B7WNL9; Q7LBY4; Q9NY13;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Cancer/testis antigen 1;
DE AltName: Full=Autoimmunogenic cancer/testis antigen NY-ESO-1;
DE AltName: Full=Cancer/testis antigen 6.1;
DE Short=CT6.1;
DE AltName: Full=L antigen family member 2;
DE Short=LAGE-2;
GN Name=CTAG1A; Synonyms=CTAG, CTAG1, ESO1, LAGE2, LAGE2A;
GN and
GN Name=CTAG1B; Synonyms=LAGE2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9050879; DOI=10.1073/pnas.94.5.1914;
RA Chen Y.-T., Scanlan M.J., Sahin U., Tuereci O., Gure A.O., Tsang S.,
RA Williamson B., Stockert E., Pfreundschuh M., Old L.J.;
RT "A testicular antigen aberrantly expressed in human cancers detected by
RT autologous antibody screening.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:1914-1918(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Melanoma;
RX PubMed=9626360;
RX DOI=10.1002/(sici)1097-0215(19980610)76:6<903::aid-ijc22>3.0.co;2-1;
RA Lethe B.G., Lucas S., Michaux L., De Smet C., Godelaine D., Serrano A.,
RA De Plaen E., Boon T.;
RT "LAGE-1, a new gene with tumor specificity.";
RL Int. J. Cancer 76:903-908(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9759882;
RA Wang R.-F., Johnston S.L., Zeng G., Topalian S.L., Schwartzentruber D.J.,
RA Rosenberg S.A.;
RT "A breast and melanoma-shared tumor antigen: T cell responses to antigenic
RT peptides translated from different open reading frames.";
RL J. Immunol. 161:3598-3606(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10523621; DOI=10.1128/mcb.19.11.7327;
RA De Smet C., Lurquin C., Lethe B.G., Martelange V., Boon T.;
RT "DNA methylation is the primary silencing mechanism for a set of germ
RT line- and tumor-specific genes with a CpG-rich promoter.";
RL Mol. Cell. Biol. 19:7327-7335(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11709543; DOI=10.1093/hmg/10.22.2557;
RA Aradhya S., Bardaro T., Galgoczy P., Yamagata T., Esposito T., Patlan H.,
RA Ciccodicola A., Kenwrick S., Platzer M., D'Urso M., Nelson D.L.;
RT "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb
RT duplication involving the NEMO and LAGE2 genes.";
RL Hum. Mol. Genet. 10:2557-2567(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 27-180 (ISOFORM 2).
RA Lethe B.G.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=12065688; DOI=10.1097/01.lab.0000017169.26718.5f;
RA Satie A.P., Rajpert-De Meyts E., Spagnoli G.C., Henno S., Olivo L.,
RA Jacobsen G.K., Rioux-Leclercq N., Jegou B., Samson M.;
RT "The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult
RT testes and in spermatocytic seminomas and testicular carcinoma in situ.";
RL Lab. Invest. 82:775-780(2002).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 157-165 IN COMPLEX WITH T-CELL
RP RECEPTOR.
RX PubMed=15837811; DOI=10.1084/jem.20042323;
RA Chen J.-L., Stewart-Jones G., Bossi G., Lissin N.M., Wooldridge L.,
RA Choi E.M.L., Held G., Dunbar P.R., Esnouf R.M., Sami M., Boulter J.M.,
RA Rizkallah P., Renner C., Sewell A., van der Merwe P.A., Jakobsen B.K.,
RA Griffiths G., Jones E.Y., Cerundolo V.;
RT "Structural and kinetic basis for heightened immunogenicity of T cell
RT vaccines.";
RL J. Exp. Med. 201:1243-1255(2005).
CC -!- INTERACTION:
CC P78358; Q08043: ACTN3; NbExp=5; IntAct=EBI-1188472, EBI-2880652;
CC P78358; O15296: ALOX15B; NbExp=3; IntAct=EBI-1188472, EBI-12150557;
CC P78358; Q8N1W1-4: ARHGEF28; NbExp=3; IntAct=EBI-1188472, EBI-13062134;
CC P78358; Q13733-2: ATP1A4; NbExp=3; IntAct=EBI-1188472, EBI-12356439;
CC P78358; P46379-2: BAG6; NbExp=3; IntAct=EBI-1188472, EBI-10988864;
CC P78358; Q9HBH7: BEX1; NbExp=5; IntAct=EBI-1188472, EBI-7162175;
CC P78358; Q9BXY8: BEX2; NbExp=5; IntAct=EBI-1188472, EBI-745073;
CC P78358; Q96LC9: BMF; NbExp=3; IntAct=EBI-1188472, EBI-3919268;
CC P78358; Q96FH0: BORCS8; NbExp=5; IntAct=EBI-1188472, EBI-744076;
CC P78358; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-1188472, EBI-725606;
CC P78358; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-1188472, EBI-8643161;
CC P78358; Q5T5Y3-3: CAMSAP1; NbExp=3; IntAct=EBI-1188472, EBI-12036363;
CC P78358; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-1188472, EBI-744311;
CC P78358; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-1188472, EBI-10175300;
CC P78358; Q16543: CDC37; NbExp=3; IntAct=EBI-1188472, EBI-295634;
CC P78358; Q96HQ2: CDKN2AIPNL; NbExp=3; IntAct=EBI-1188472, EBI-10038935;
CC P78358; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-1188472, EBI-2321769;
CC P78358; Q9H0L4: CSTF2T; NbExp=3; IntAct=EBI-1188472, EBI-747012;
CC P78358; P78358: CTAG1B; NbExp=3; IntAct=EBI-1188472, EBI-1188472;
CC P78358; Q9UIA0: CYTH4; NbExp=3; IntAct=EBI-1188472, EBI-11521003;
CC P78358; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-1188472, EBI-742054;
CC P78358; Q6ICB0: DESI1; NbExp=3; IntAct=EBI-1188472, EBI-2806959;
CC P78358; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-1188472, EBI-11958845;
CC P78358; A1L4K1: FSD2; NbExp=3; IntAct=EBI-1188472, EBI-5661036;
CC P78358; O43716: GATC; NbExp=3; IntAct=EBI-1188472, EBI-6929453;
CC P78358; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-1188472, EBI-11427343;
CC P78358; Q9Y4H4: GPSM3; NbExp=5; IntAct=EBI-1188472, EBI-347538;
CC P78358; P78347-2: GTF2I; NbExp=5; IntAct=EBI-1188472, EBI-12033200;
CC P78358; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-1188472, EBI-11978177;
CC P78358; P08631-2: HCK; NbExp=3; IntAct=EBI-1188472, EBI-9834454;
CC P78358; Q9Y5R4: HEMK1; NbExp=3; IntAct=EBI-1188472, EBI-10329202;
CC P78358; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-1188472, EBI-740641;
CC P78358; Q9ULI4: KIF26A; NbExp=3; IntAct=EBI-1188472, EBI-1642152;
CC P78358; Q2WGJ6: KLHL38; NbExp=5; IntAct=EBI-1188472, EBI-6426443;
CC P78358; Q6IAA8: LAMTOR1; NbExp=3; IntAct=EBI-1188472, EBI-715385;
CC P78358; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-1188472, EBI-12133176;
CC P78358; Q496Y0: LONRF3; NbExp=3; IntAct=EBI-1188472, EBI-2690768;
CC P78358; O60732: MAGEC1; NbExp=6; IntAct=EBI-1188472, EBI-1188463;
CC P78358; O14770-4: MEIS2; NbExp=3; IntAct=EBI-1188472, EBI-8025850;
CC P78358; A6NI15: MSGN1; NbExp=3; IntAct=EBI-1188472, EBI-11991020;
CC P78358; Q15742: NAB2; NbExp=3; IntAct=EBI-1188472, EBI-8641936;
CC P78358; P62166: NCS1; NbExp=3; IntAct=EBI-1188472, EBI-746987;
CC P78358; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-1188472, EBI-741158;
CC P78358; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-1188472, EBI-10181968;
CC P78358; Q9UBV8: PEF1; NbExp=3; IntAct=EBI-1188472, EBI-724639;
CC P78358; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-1188472, EBI-10232538;
CC P78358; Q6PIY2: POLM; NbExp=3; IntAct=EBI-1188472, EBI-10253863;
CC P78358; P20618: PSMB1; NbExp=3; IntAct=EBI-1188472, EBI-372273;
CC P78358; Q6VN20: RANBP10; NbExp=3; IntAct=EBI-1188472, EBI-310569;
CC P78358; Q96EN9: REX1BD; NbExp=3; IntAct=EBI-1188472, EBI-745810;
CC P78358; Q7L4I2: RSRC2; NbExp=3; IntAct=EBI-1188472, EBI-953753;
CC P78358; Q8WWV3: RTN4IP1; NbExp=6; IntAct=EBI-1188472, EBI-743502;
CC P78358; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-1188472, EBI-6257312;
CC P78358; Q9UDX3: SEC14L4; NbExp=3; IntAct=EBI-1188472, EBI-10320311;
CC P78358; O43765: SGTA; NbExp=3; IntAct=EBI-1188472, EBI-347996;
CC P78358; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-1188472, EBI-744081;
CC P78358; Q9BRV8: SIKE1; NbExp=3; IntAct=EBI-1188472, EBI-1773646;
CC P78358; Q9H0W8: SMG9; NbExp=5; IntAct=EBI-1188472, EBI-2872322;
CC P78358; Q5JUK2: SOHLH1; NbExp=5; IntAct=EBI-1188472, EBI-12288855;
CC P78358; Q99932-2: SPAG8; NbExp=5; IntAct=EBI-1188472, EBI-11959123;
CC P78358; Q7Z7C7: STRA8; NbExp=3; IntAct=EBI-1188472, EBI-12036261;
CC P78358; P51687: SUOX; NbExp=3; IntAct=EBI-1188472, EBI-3921347;
CC P78358; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-1188472, EBI-11955057;
CC P78358; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-1188472, EBI-11139477;
CC P78358; Q96FV9: THOC1; NbExp=3; IntAct=EBI-1188472, EBI-1765605;
CC P78358; O14787-2: TNPO2; NbExp=3; IntAct=EBI-1188472, EBI-12076664;
CC P78358; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-1188472, EBI-492476;
CC P78358; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-1188472, EBI-10241197;
CC P78358; Q13404: UBE2V1; NbExp=3; IntAct=EBI-1188472, EBI-1050671;
CC P78358; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-1188472, EBI-607755;
CC P78358; Q9UMX0: UBQLN1; NbExp=6; IntAct=EBI-1188472, EBI-741480;
CC P78358; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-1188472, EBI-10173939;
CC P78358; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-1188472, EBI-947187;
CC P78358; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-1188472, EBI-14096082;
CC P78358; O95231: VENTX; NbExp=5; IntAct=EBI-1188472, EBI-10191303;
CC P78358; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-1188472, EBI-12040603;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12065688}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P78358-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P78358-2; Sequence=VSP_028548;
CC -!- TISSUE SPECIFICITY: Expressed in testis and ovary and in a wide variety
CC of cancers. Detected in uterine myometrium. Expressed from 18 weeks
CC until birth in human fetal testis. In the adult testis, is strongly
CC expressed in spermatogonia and in primary spermatocytes, but not in
CC post-meiotic cells or in testicular somatic cells (at protein level).
CC {ECO:0000269|PubMed:12065688}.
CC -!- SIMILARITY: Belongs to the CTAG/PCC1 family. {ECO:0000305}.
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DR EMBL; U87459; AAB49693.1; -; mRNA.
DR EMBL; AJ003149; CAA05908.1; -; mRNA.
DR EMBL; AF038567; AAD05202.1; -; mRNA.
DR EMBL; AJ275977; CAB76943.1; -; Genomic_DNA.
DR EMBL; AF277315; AAL27013.1; -; Genomic_DNA.
DR EMBL; AF277315; AAL27014.1; -; Genomic_DNA.
DR EMBL; CH471172; EAW72673.1; -; Genomic_DNA.
DR EMBL; CH471172; EAW72674.1; -; Genomic_DNA.
DR EMBL; BC130362; AAI30363.1; -; mRNA.
DR EMBL; BC130364; AAI30365.1; -; mRNA.
DR EMBL; AJ275978; CAB76945.1; -; mRNA.
DR CCDS; CCDS14758.1; -. [P78358-1]
DR CCDS; CCDS44025.1; -. [P78358-1]
DR RefSeq; NP_001318.1; NM_001327.2. [P78358-1]
DR RefSeq; NP_640343.1; NM_139250.1. [P78358-1]
DR PDB; 1S9W; X-ray; 2.20 A; C=157-165.
DR PDB; 2BNQ; X-ray; 1.70 A; C=157-164.
DR PDB; 2BNR; X-ray; 1.90 A; C=157-165.
DR PDB; 2F53; X-ray; 2.10 A; C=157-165.
DR PDB; 2F54; X-ray; 2.70 A; C/H=157-165.
DR PDB; 2P5E; X-ray; 1.89 A; C=157-165.
DR PDB; 2P5W; X-ray; 2.20 A; C=157-165.
DR PDB; 2PYE; X-ray; 2.30 A; C=157-165.
DR PDB; 3GJF; X-ray; 1.90 A; C/F=157-164.
DR PDB; 3HAE; X-ray; 2.90 A; C/F/M/R=157-164.
DR PDB; 3KLA; X-ray; 1.65 A; C/F=157-165.
DR PDB; 6AT5; X-ray; 1.50 A; C=60-72.
DR PDB; 6AVF; X-ray; 2.03 A; P=60-72.
DR PDB; 6AVG; X-ray; 2.60 A; P/Q=60-72.
DR PDB; 6RP9; X-ray; 3.12 A; C/H=157-165.
DR PDB; 6RPA; X-ray; 2.56 A; C=157-164.
DR PDB; 6RPB; X-ray; 2.50 A; C/H/M/R=157-164.
DR PDBsum; 1S9W; -.
DR PDBsum; 2BNQ; -.
DR PDBsum; 2BNR; -.
DR PDBsum; 2F53; -.
DR PDBsum; 2F54; -.
DR PDBsum; 2P5E; -.
DR PDBsum; 2P5W; -.
DR PDBsum; 2PYE; -.
DR PDBsum; 3GJF; -.
DR PDBsum; 3HAE; -.
DR PDBsum; 3KLA; -.
DR PDBsum; 6AT5; -.
DR PDBsum; 6AVF; -.
DR PDBsum; 6AVG; -.
DR PDBsum; 6RP9; -.
DR PDBsum; 6RPA; -.
DR PDBsum; 6RPB; -.
DR AlphaFoldDB; P78358; -.
DR SMR; P78358; -.
DR BioGRID; 107867; 118.
DR BioGRID; 128863; 79.
DR IntAct; P78358; 76.
DR STRING; 9606.ENSP00000332602; -.
DR iPTMnet; P78358; -.
DR PhosphoSitePlus; P78358; -.
DR BioMuta; CTAG1A; -.
DR DMDM; 6014739; -.
DR MassIVE; P78358; -.
DR PaxDb; P78358; -.
DR PeptideAtlas; P78358; -.
DR PRIDE; P78358; -.
DR ProteomicsDB; 57589; -. [P78358-1]
DR ProteomicsDB; 57590; -. [P78358-2]
DR TopDownProteomics; P78358-1; -. [P78358-1]
DR ABCD; P78358; 2 sequenced antibodies.
DR Antibodypedia; 4225; 860 antibodies from 28 providers.
DR Antibodypedia; 74750; 45 antibodies from 14 providers.
DR DNASU; 246100; -.
DR Ensembl; ENST00000328435.3; ENSP00000332602.2; ENSG00000184033.14. [P78358-1]
DR Ensembl; ENST00000359887.4; ENSP00000352953.4; ENSG00000184033.14. [P78358-2]
DR Ensembl; ENST00000593606.3; ENSP00000472220.3; ENSG00000268651.4. [P78358-2]
DR Ensembl; ENST00000599837.3; ENSP00000469441.1; ENSG00000268651.4. [P78358-1]
DR GeneID; 1485; -.
DR GeneID; 246100; -.
DR KEGG; hsa:1485; -.
DR KEGG; hsa:246100; -.
DR MANE-Select; ENST00000328435.3; ENSP00000332602.2; NM_001327.3; NP_001318.1.
DR MANE-Select; ENST00000599837.3; ENSP00000469441.1; NM_139250.2; NP_640343.1.
DR UCSC; uc004fme.3; human. [P78358-1]
DR CTD; 1485; -.
DR CTD; 246100; -.
DR DisGeNET; 1485; -.
DR DisGeNET; 246100; -.
DR GeneCards; CTAG1A; -.
DR GeneCards; CTAG1B; -.
DR HGNC; HGNC:24198; CTAG1A.
DR HGNC; HGNC:2491; CTAG1B.
DR HPA; ENSG00000184033; Tissue enriched (testis).
DR HPA; ENSG00000268651; Tissue enriched (testis).
DR MIM; 300156; gene.
DR MIM; 300657; gene.
DR neXtProt; NX_P78358; -.
DR OpenTargets; ENSG00000184033; -.
DR PharmGKB; PA134979749; -.
DR VEuPathDB; HostDB:ENSG00000184033; -.
DR VEuPathDB; HostDB:ENSG00000268651; -.
DR eggNOG; ENOG502TM3F; Eukaryota.
DR GeneTree; ENSGT00410000025802; -.
DR HOGENOM; CLU_113770_0_0_1; -.
DR InParanoid; P78358; -.
DR OMA; LMWIMQC; -.
DR OrthoDB; 1584653at2759; -.
DR PhylomeDB; P78358; -.
DR TreeFam; TF337064; -.
DR PathwayCommons; P78358; -.
DR SignaLink; P78358; -.
DR BioGRID-ORCS; 1485; 111 hits in 593 CRISPR screens.
DR BioGRID-ORCS; 246100; 14 hits in 579 CRISPR screens.
DR EvolutionaryTrace; P78358; -.
DR GeneWiki; CTAG1B; -.
DR Pharos; P78358; Tbio.
DR PRO; PR:P78358; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P78358; protein.
DR Bgee; ENSG00000184033; Expressed in testis and 29 other tissues.
DR ExpressionAtlas; P78358; baseline.
DR Genevisible; P78358; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0070525; P:tRNA threonylcarbamoyladenosine metabolic process; IBA:GO_Central.
DR InterPro; IPR015419; CTAG/Pcc1.
DR PANTHER; PTHR31283; PTHR31283; 1.
DR Pfam; PF09341; Pcc1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..180
FT /note="Cancer/testis antigen 1"
FT /id="PRO_0000218922"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 135..180
FT /note="IRLTAADHRQLQLSISSCLQQLSLLMWITQCFLPVFLAQPPSGQRR -> MS
FT VQDQDRDGAWVGGGHSVAGWGLGSAYTPRSGC (in isoform 2)"
FT /evidence="ECO:0000303|Ref.9"
FT /id="VSP_028548"
FT HELIX 64..66
FT /evidence="ECO:0007829|PDB:6AVF"
FT TURN 67..69
FT /evidence="ECO:0007829|PDB:6AVF"
SQ SEQUENCE 180 AA; 17992 MW; B122C5C2C8BE1569 CRC64;
MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA
PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG
VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR
