CTG1_CAEEL
ID CTG1_CAEEL Reviewed; 383 AA.
AC O17907; K8ES75; K8F7T8;
DT 26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Protein ctg-1 {ECO:0000305};
GN Name=ctg-1 {ECO:0000312|WormBase:H06O01.3a};
GN ORFNames=H06O01.3 {ECO:0000312|WormBase:H06O01.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=27661254; DOI=10.7554/elife.17218;
RA McClatchey S.T., Wang Z., Linden L.M., Hastie E.L., Wang L., Shen W.,
RA Chen A., Chi Q., Sherwood D.R.;
RT "Boundary cells restrict dystroglycan trafficking to control basement
RT membrane sliding during tissue remodeling.";
RL Elife 5:0-0(2016).
CC -!- FUNCTION: Vesicle trafficking protein (Probable). Functions in uterine
CC cells to promote basement membrane (BM) mobility and BM gap formation
CC during tissue remodeling (PubMed:27661254).
CC {ECO:0000269|PubMed:27661254, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:27661254}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a {ECO:0000312|WormBase:H06O01.3a};
CC IsoId=O17907-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:H06O01.3b};
CC IsoId=O17907-2; Sequence=VSP_060471;
CC Name=c {ECO:0000312|WormBase:H06O01.3c};
CC IsoId=O17907-3; Sequence=VSP_060470;
CC -!- TISSUE SPECIFICITY: Highly expressed in cells of the pi uterine cell
CC lineage. {ECO:0000269|PubMed:27661254}.
CC -!- DEVELOPMENTAL STAGE: Expressed in cells of the pi uterine cell lineage
CC during the 8-cell stage of development. {ECO:0000269|PubMed:27661254}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in cells of the pi
CC uterine cell lineage impairs basement membrane (BM) sliding along each
CC other and reduces the size of BM openings.
CC {ECO:0000269|PubMed:27661254}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284601; CAB07482.1; -; Genomic_DNA.
DR EMBL; BX284601; CCO25611.1; -; Genomic_DNA.
DR EMBL; BX284601; CCO25612.1; -; Genomic_DNA.
DR PIR; T23057; T23057.
DR RefSeq; NP_001263451.1; NM_001276522.1. [O17907-2]
DR RefSeq; NP_001263452.1; NM_001276523.1. [O17907-3]
DR RefSeq; NP_491993.1; NM_059592.5. [O17907-1]
DR AlphaFoldDB; O17907; -.
DR SMR; O17907; -.
DR DIP; DIP-25940N; -.
DR STRING; 6239.H06O01.3a; -.
DR EPD; O17907; -.
DR PaxDb; O17907; -.
DR PeptideAtlas; O17907; -.
DR EnsemblMetazoa; H06O01.3a.1; H06O01.3a.1; WBGene00010370. [O17907-1]
DR EnsemblMetazoa; H06O01.3b.1; H06O01.3b.1; WBGene00010370. [O17907-2]
DR EnsemblMetazoa; H06O01.3c.1; H06O01.3c.1; WBGene00010370. [O17907-3]
DR GeneID; 172431; -.
DR KEGG; cel:CELE_H06O01.3; -.
DR UCSC; H06O01.3; c. elegans. [O17907-1]
DR CTD; 172431; -.
DR WormBase; H06O01.3a; CE17969; WBGene00010370; ctg-1. [O17907-1]
DR WormBase; H06O01.3b; CE48027; WBGene00010370; ctg-1. [O17907-2]
DR WormBase; H06O01.3c; CE47872; WBGene00010370; ctg-1. [O17907-3]
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000170522; -.
DR HOGENOM; CLU_014001_2_1_1; -.
DR InParanoid; O17907; -.
DR OMA; VYIEQMG; -.
DR OrthoDB; 1133487at2759; -.
DR PhylomeDB; O17907; -.
DR PRO; PR:O17907; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00010370; Expressed in larva and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0110011; P:regulation of basement membrane organization; IMP:UniProtKB.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..383
FT /note="Protein ctg-1"
FT /id="PRO_0000448938"
FT DOMAIN 73..247
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT DOMAIN 271..380
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT VAR_SEQ 1..144
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_060470"
FT VAR_SEQ 1..95
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_060471"
SQ SEQUENCE 383 AA; 43847 MW; 51E1224C994EFD3F CRC64;
MLVSPTAAAT SIEQQTIRDL RSIVPQIDNL NDGYVLRWLR AKEGRFDETA ESLKKHVTFR
NAWHLDKIEQ WTPPECLEKY CGYGLLGDTE GRPILMSLLG NVDVEGLLRS VASLDYIKFS
LAAIEKGMKL CEEKAKESGR PFEQMTLVFD LENITSAHFS CKQFASSFTT LVSLFQDHYP
LFLRKILIIR APEMARIAYA SITAILQDPI TRLVEMPSES DWKWSLAQIV NLDAWPMYWG
GNLVENGDPK CPSRIKYGGG AVDESYFVDP KKAMADYDQL TTVYAGDKHL IQIKVKRPSR
ISWTYMTDED DIGFEIHYDK TGSCDKLTEM ETVYPYIRLE CTNVPITGHL DVTDVGNYVL
EFDNYYSWFS AKQLRYNIEI EDL
