ID   CTGE1_HUMAN             Reviewed;          74 AA.
AC   Q9HC47; B0YIZ3;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Cutaneous T-cell lymphoma-associated antigen 1;
DE            Short=Protein cTAGE-1;
DE   AltName: Full=Cancer/testis antigen 21.1;
DE            Short=CT21.1;
GN   Name=CTAGE1; Synonyms=CTAGE2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11149944; DOI=10.1073/pnas.98.2.629;
RA   Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.;
RT   "Serological detection of cutaneous T-cell lymphoma-associated antigens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND ALTERNATIVE SPLICING.
RC   TISSUE=Testis;
RX   PubMed=12839582; DOI=10.1046/j.1523-1747.2003.12318.x;
RA   Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S.;
RT   "cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-
RT   specific splicing.";
RL   J. Invest. Dermatol. 121:198-206(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   NHLBI resequencing and genotyping service (RS&G);
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms (cTAGE-1B, cTAGE-1C and cTAGE-2s) exist.;
CC       Name=1; Synonyms=cTAGE-1;
CC         IsoId=Q9HC47-1; Sequence=Displayed;
CC       Name=2; Synonyms=cTAGE-2;
CC         IsoId=Q96RT6-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Testis. Expressed in several cutaneous T-cell
CC       lymphoma (CTCL) cell lines, in head-neck carcinomas and carcinoma of
CC       ovarian tissues. {ECO:0000269|PubMed:11149944}.
CC   -!- MISCELLANEOUS: Cancer-testis antigen containing the epitope FVLFLFGGN
CC       which is detected in sera of CTCL patients according to
CC       PubMed:12839582. Tumor-associated antigen found in several cutaneous T-
CC       cell lymphoma (CTCL), and in particular in mycosis fungoides patients
CC       and in Sezary syndrome patients. Detected by 5 of 15 sera of Mycosis
CC       fungoides patients and by 2 of 3 sera of Sezary syndrome patients, but
CC       not by any control sera. Expressed in around 35% of the tested CTCL
CC       tumors.
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DR   EMBL; AF177229; AAG23843.1; -; mRNA.
DR   EMBL; EF444969; ACA05971.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HC47; -.
DR   BioMuta; CTAGE1; -.
DR   MaxQB; Q9HC47; -.
DR   PaxDb; Q9HC47; -.
DR   PRIDE; Q9HC47; -.
DR   Antibodypedia; 4258; 132 antibodies from 23 providers.
DR   Ensembl; ENST00000525417.1; ENSP00000436900.1; ENSG00000212710.5. [Q9HC47-1]
DR   Ensembl; ENST00000634570.1; ENSP00000489506.1; ENSG00000282841.2. [Q9HC47-1]
DR   UCSC; uc060nvt.1; human. [Q9HC47-1]
DR   GeneCards; CTAGE1; -.
DR   HGNC; HGNC:24346; CTAGE1.
DR   HPA; ENSG00000212710; Tissue enriched (testis).
DR   MIM; 608856; gene.
DR   neXtProt; NX_Q9HC47; -.
DR   OpenTargets; ENSG00000212710; -.
DR   VEuPathDB; HostDB:ENSG00000212710; -.
DR   GeneTree; ENSGT00950000182767; -.
DR   HOGENOM; CLU_183161_0_0_1; -.
DR   PhylomeDB; Q9HC47; -.
DR   PathwayCommons; Q9HC47; -.
DR   Pharos; Q9HC47; Tbio.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000212710; Expressed in right testis and 11 other tissues.
DR   ExpressionAtlas; Q9HC47; baseline and differential.
DR   Genevisible; Q9HC47; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..74
FT                   /note="Cutaneous T-cell lymphoma-associated antigen 1"
FT                   /id="PRO_0000189537"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   74 AA;  8406 MW;  9F527C464350E8D0 CRC64;
     MFVIISLHNC VVISFVLFLF GGNNFIQNFY LPQNYIDQFL LTSFPTFTSV GVLIVLVLCS
     AFLLLWQGEG VNLR