CTGE2_HUMAN
ID CTGE2_HUMAN Reviewed; 745 AA.
AC Q96RT6; A2RUF2;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=cTAGE family member 2;
DE Short=Protein cTAGE-2;
DE AltName: Full=Cancer/testis antigen 21.2;
DE Short=CT21.2;
GN Name=CTAGE1; Synonyms=CTAGE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=12839582; DOI=10.1046/j.1523-1747.2003.12318.x;
RA Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S.;
RT "cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-
RT specific splicing.";
RL J. Invest. Dermatol. 121:198-206(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=Additional isoforms (cTAGE-1B, cTAGE-1C and cTAGE-2s) exist.;
CC Name=2; Synonyms=cTAGE-2;
CC IsoId=Q96RT6-1; Sequence=Displayed;
CC Name=1; Synonyms=cTAGE-1;
CC IsoId=Q9HC47-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Testis. Not found in tumor.
CC -!- SIMILARITY: Belongs to the cTAGE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK63198.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF273058; AAK63198.1; ALT_FRAME; mRNA.
DR EMBL; AC099849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132871; AAI32872.1; -; mRNA.
DR CCDS; CCDS45837.1; -. [Q96RT6-1]
DR RefSeq; NP_758441.2; NM_172241.2. [Q96RT6-1]
DR AlphaFoldDB; Q96RT6; -.
DR SMR; Q96RT6; -.
DR BioGRID; 122233; 6.
DR IntAct; Q96RT6; 8.
DR MINT; Q96RT6; -.
DR STRING; 9606.ENSP00000375220; -.
DR iPTMnet; Q96RT6; -.
DR PhosphoSitePlus; Q96RT6; -.
DR BioMuta; CTAGE1; -.
DR DMDM; 209572622; -.
DR EPD; Q96RT6; -.
DR jPOST; Q96RT6; -.
DR MassIVE; Q96RT6; -.
DR PaxDb; Q96RT6; -.
DR PeptideAtlas; Q96RT6; -.
DR PRIDE; Q96RT6; -.
DR ProteomicsDB; 78028; -. [Q96RT6-1]
DR Antibodypedia; 4258; 132 antibodies from 23 providers.
DR DNASU; 64693; -.
DR Ensembl; ENST00000391403.4; ENSP00000375220.2; ENSG00000212710.5. [Q96RT6-1]
DR Ensembl; ENST00000634260.2; ENSP00000489019.1; ENSG00000282841.2. [Q96RT6-1]
DR GeneID; 64693; -.
DR KEGG; hsa:64693; -.
DR MANE-Select; ENST00000391403.4; ENSP00000375220.2; NM_172241.3; NP_758441.2.
DR UCSC; uc002ktv.2; human. [Q96RT6-1]
DR CTD; 64693; -.
DR DisGeNET; 64693; -.
DR GeneCards; CTAGE1; -.
DR HGNC; HGNC:24346; CTAGE1.
DR HPA; ENSG00000212710; Tissue enriched (testis).
DR MIM; 608856; gene.
DR neXtProt; NX_Q96RT6; -.
DR OpenTargets; ENSG00000212710; -.
DR PharmGKB; PA134933936; -.
DR VEuPathDB; HostDB:ENSG00000212710; -.
DR eggNOG; ENOG502QUND; Eukaryota.
DR GeneTree; ENSGT00950000182767; -.
DR HOGENOM; CLU_002106_2_0_1; -.
DR InParanoid; Q96RT6; -.
DR OMA; HFESEVQ; -.
DR PhylomeDB; Q96RT6; -.
DR TreeFam; TF333137; -.
DR PathwayCommons; Q96RT6; -.
DR SignaLink; Q96RT6; -.
DR BioGRID-ORCS; 64693; 18 hits in 1000 CRISPR screens.
DR GenomeRNAi; 64693; -.
DR Pharos; Q96RT6; Tbio.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q96RT6; protein.
DR Bgee; ENSG00000212710; Expressed in right testis and 11 other tissues.
DR ExpressionAtlas; Q96RT6; baseline and differential.
DR Genevisible; Q96RT6; HS.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0035459; P:vesicle cargo loading; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..745
FT /note="cTAGE family member 2"
FT /id="PRO_0000189538"
FT TRANSMEM 13..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 508..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 84..254
FT /evidence="ECO:0000255"
FT COILED 290..411
FT /evidence="ECO:0000255"
FT COMPBIAS 536..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 267
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VARIANT 682
FT /note="I -> V (in dbSNP:rs9946136)"
FT /id="VAR_046956"
FT CONFLICT 179
FT /note="Q -> R (in Ref. 1; AAK63198)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="E -> G (in Ref. 1; AAK63198)"
FT /evidence="ECO:0000305"
FT CONFLICT 430
FT /note="H -> R (in Ref. 1; AAK63198)"
FT /evidence="ECO:0000305"
FT CONFLICT 635
FT /note="T -> A (in Ref. 1; AAK63198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 745 AA; 85282 MW; E3E6B1219651CA61 CRC64;
MRPDSHPYGF PWELVIRAAV AGFFAVLFLW RSFRSVTSRL YVRREKKFAV ALSGLIEEKC
KLLEKFSLVQ KEYEGYEVES SLKNASFEKE ATEAQSLEAT CEKLNRFNSE LVHEILCLEK
ELKEEKSKHS EQNELMADIS KRIQSLEDES KSLKSQVAEA KMTFKRFQAN EERLEIEIQD
AWKENSELQE SQKQLLQEAE VWKEQVSELI KQKRTFEDSK VHAEQVLNDK ENHIKTLTER
LLKMKDGVAM LEEDVTDDDN LELEMNSESE DGAYLDNPPK GALKKLIHAA KLNASLKTLE
GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FESENQKLQQ KLKVMTELYQ
ENEMKLYRKL IVEEKCRLEK EEKLSKVDEM ISHATEELET YRKRAKDLKE FEKTIHFYQK
KIILHEKKAH DNWSAAWTAE RNLNDLRKEN AHNRQKLTEI EFKIKLLEKD PYGLDVPNTA
FGRQHSPYGP SPLGWPSSET RASLYPPTLL EGPLRLSPLL PRGGGRGSRG PGNPPDHQIT
KERGESSCDR LTDPHRAPSD AGPLAPPWEQ DYRMMFPPPG QSYPDSALPP QRQDRFYSNC
ARLSGPAELR SFNMPSLDKM DGSMPSEMES SRNDTKDNLG NLKVPDSSLP AENEATGPGF
VPPPLAPIRG LLFPVDTRGP FIRRGPPFPP PPPGTVFGAS PDYFSPRDVP GPPRAPFAMR
NVYLPRGFLP YRPPRPAFFP PAPTF
