CTGE4_HUMAN
ID CTGE4_HUMAN Reviewed; 777 AA.
AC Q8IX94; A8K871; O95046;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=cTAGE family member 4;
DE Short=Protein cTAGE-4;
GN Name=CTAGE4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 209-674, AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12839582; DOI=10.1046/j.1523-1747.2003.12318.x;
RA Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S.;
RT "cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-
RT specific splicing.";
RL J. Invest. Dermatol. 121:198-206(2003).
CC -!- FUNCTION: Tumor-associated antigen.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in testis, placenta and skin. Expressed
CC at lower level in mammary gland and stomach.
CC {ECO:0000269|PubMed:12839582}.
CC -!- MISCELLANEOUS: Tumor-associated antigen found in several cutaneous T-
CC cell lymphoma (CTCL). Also found in colorectal and breast carcinomas,
CC head and neck squamous cell carcinomas and melanoma.
CC -!- SIMILARITY: Belongs to the cTAGE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN77609.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAN77609.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK292236; BAF84925.1; -; mRNA.
DR EMBL; AC004889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF338232; AAN77609.1; ALT_SEQ; mRNA.
DR CCDS; CCDS55176.1; -.
DR RefSeq; NP_001265436.1; NM_001278507.1.
DR RefSeq; NP_940897.2; NM_198495.2.
DR AlphaFoldDB; Q8IX94; -.
DR SMR; Q8IX94; -.
DR BioGRID; 936688; 1.
DR iPTMnet; Q8IX94; -.
DR PhosphoSitePlus; Q8IX94; -.
DR BioMuta; CTAGE4; -.
DR DMDM; 229462987; -.
DR jPOST; Q8IX94; -.
DR MassIVE; Q8IX94; -.
DR MaxQB; Q8IX94; -.
DR PaxDb; Q8IX94; -.
DR PeptideAtlas; Q8IX94; -.
DR PRIDE; Q8IX94; -.
DR Antibodypedia; 56189; 63 antibodies from 11 providers.
DR DNASU; 100128553; -.
DR Ensembl; ENST00000486333.2; ENSP00000419539.1; ENSG00000288784.1.
DR GeneID; 100128553; -.
DR GeneID; 100142659; -.
DR KEGG; hsa:100128553; -.
DR KEGG; hsa:100142659; -.
DR MANE-Select; ENST00000486333.2; ENSP00000419539.1; NM_198495.3; NP_940897.2.
DR UCSC; uc010lpc.5; human.
DR CTD; 100128553; -.
DR CTD; 100142659; -.
DR GeneCards; CTAGE4; -.
DR HGNC; HGNC:24772; CTAGE4.
DR HPA; ENSG00000225932; Tissue enhanced (testis).
DR MIM; 608910; gene.
DR neXtProt; NX_Q8IX94; -.
DR PharmGKB; PA134946406; -.
DR VEuPathDB; HostDB:ENSG00000225932; -.
DR eggNOG; ENOG502QUND; Eukaryota.
DR GeneTree; ENSGT00950000182767; -.
DR HOGENOM; CLU_002106_2_0_1; -.
DR InParanoid; Q8IX94; -.
DR OMA; HRMIFPP; -.
DR OrthoDB; 104022at2759; -.
DR PhylomeDB; Q8IX94; -.
DR TreeFam; TF333137; -.
DR PathwayCommons; Q8IX94; -.
DR BioGRID-ORCS; 100128553; 28 hits in 602 CRISPR screens.
DR BioGRID-ORCS; 100142659; 53 hits in 179 CRISPR screens.
DR ChiTaRS; CTAGE4; human.
DR Pharos; Q8IX94; Tdark.
DR PRO; PR:Q8IX94; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IX94; protein.
DR Bgee; ENSG00000225932; Expressed in lower esophagus mucosa and 86 other tissues.
DR Genevisible; Q8IX94; HS.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0035459; P:vesicle cargo loading; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..777
FT /note="cTAGE family member 4"
FT /id="PRO_0000189540"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 510..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..269
FT /evidence="ECO:0000255"
FT COILED 339..494
FT /evidence="ECO:0000255"
FT COMPBIAS 524..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 155
FT /note="E -> Q (in Ref. 1; BAF84925)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="E -> Q (in Ref. 1; BAF84925)"
FT /evidence="ECO:0000305"
FT CONFLICT 568
FT /note="L -> P (in Ref. 1; BAF84925)"
FT /evidence="ECO:0000305"
FT CONFLICT 655
FT /note="R -> G (in Ref. 3; AAN77609)"
FT /evidence="ECO:0000305"
FT CONFLICT 662
FT /note="E -> G (in Ref. 3; AAN77609)"
FT /evidence="ECO:0000305"
FT CONFLICT 701..702
FT /note="IS -> VR (in Ref. 1; BAF84925)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 777 AA; 87989 MW; AEB0C9DBAC58AC8A CRC64;
MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGEVSE
LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE
EKISRATEGL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ
TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP
VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE
MESSRNDAKD DLGNLNVPDS SLPAENEATG PGLIPPPLAP ISGPLFPVDT RGPFMRRGPP
FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF
