ID   CTGE6_HUMAN             Reviewed;         777 AA.
AC   Q86UF2; A4FU29; Q3ZCM5;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=cTAGE family member 6;
DE            Short=Protein cTAGE-6;
GN   Name=CTAGE6; Synonyms=CTAGE6P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cTAGE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BC043153; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC106862; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC043153; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC101323; AAI01324.1; -; mRNA.
DR   EMBL; BC101324; AAI01325.1; -; mRNA.
DR   CCDS; CCDS64790.1; -.
DR   RefSeq; NP_848656.2; NM_178561.4.
DR   AlphaFoldDB; Q86UF2; -.
DR   SMR; Q86UF2; -.
DR   BioGRID; 131033; 5.
DR   IntAct; Q86UF2; 2.
DR   STRING; 9606.ENSP00000474388; -.
DR   iPTMnet; Q86UF2; -.
DR   PhosphoSitePlus; Q86UF2; -.
DR   BioMuta; CTAGE6; -.
DR   DMDM; 259016213; -.
DR   EPD; Q86UF2; -.
DR   jPOST; Q86UF2; -.
DR   MassIVE; Q86UF2; -.
DR   MaxQB; Q86UF2; -.
DR   PeptideAtlas; Q86UF2; -.
DR   PRIDE; Q86UF2; -.
DR   ProteomicsDB; 69815; -.
DR   Antibodypedia; 70774; 55 antibodies from 12 providers.
DR   DNASU; 340307; -.
DR   Ensembl; ENST00000470691.2; ENSP00000474388.1; ENSG00000271321.1.
DR   Ensembl; ENST00000643756.1; ENSP00000493497.1; ENSG00000285123.1.
DR   GeneID; 340307; -.
DR   KEGG; hsa:340307; -.
DR   MANE-Select; ENST00000470691.2; ENSP00000474388.1; NM_178561.5; NP_848656.2.
DR   UCSC; uc003wdk.5; human.
DR   CTD; 340307; -.
DR   GeneCards; CTAGE6; -.
DR   HGNC; HGNC:28644; CTAGE6.
DR   HPA; ENSG00000271321; Tissue enriched (testis).
DR   neXtProt; NX_Q86UF2; -.
DR   PharmGKB; PA165617921; -.
DR   VEuPathDB; HostDB:ENSG00000271321; -.
DR   eggNOG; ENOG502QUND; Eukaryota.
DR   GeneTree; ENSGT00950000182767; -.
DR   HOGENOM; CLU_002106_2_0_1; -.
DR   InParanoid; Q86UF2; -.
DR   OMA; NICPPRG; -.
DR   OrthoDB; 135910at2759; -.
DR   PhylomeDB; Q86UF2; -.
DR   PathwayCommons; Q86UF2; -.
DR   SignaLink; Q86UF2; -.
DR   BioGRID-ORCS; 340307; 14 hits in 239 CRISPR screens.
DR   GenomeRNAi; 340307; -.
DR   Pharos; Q86UF2; Tdark.
DR   PRO; PR:Q86UF2; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q86UF2; protein.
DR   Bgee; ENSG00000271321; Expressed in right testis and 44 other tissues.
DR   Genevisible; Q86UF2; HS.
DR   GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   GO; GO:0035459; P:vesicle cargo loading; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..777
FT                   /note="cTAGE family member 6"
FT                   /id="PRO_0000384149"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          541..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          118..269
FT                   /evidence="ECO:0000255"
FT   COILED          339..498
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        575..589
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        237
FT                   /note="E -> Q (in Ref. 2; AAI01324/AAI01325)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        296
FT                   /note="E -> K (in Ref. 2; AAI01324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        311
FT                   /note="L -> P (in Ref. 2; AAI01324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        348
FT                   /note="T -> S (in Ref. 2; AAI01325)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        364
FT                   /note="E -> A (in Ref. 2; AAI01325)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        412
FT                   /note="E -> G (in Ref. 2; BC043153)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   777 AA;  87900 MW;  CD26899AC51E30C0 CRC64;
     MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
     RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
     AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
     SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGEVSE
     LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
     WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
     TQQESLQSEN IYFESENQKL QQKLKIMTEF YQEDEMKLYR KLTVEENYRI EEEEKLSKVE
     EKLSRATEQL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
     KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHAP NGPAPLGQRS SETRAFLSPQ
     TLLEDPLGLS PVLPEGGGRG PRGPGNPLDH QITNERGEPS CDRLTDPHRA PSDTGSLSSP
     VEQDCKMMFP PPGQSYPDSA LPPQREDRFY SNSERLSGSA EPRSFKMTSL DKMDGSMPSE
     MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP
     FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYFHPRPG FYPNPAF