CTGE8_HUMAN
ID CTGE8_HUMAN Reviewed; 777 AA.
AC P0CG41;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=cTAGE family member 8;
DE Short=Protein cTAGE-8;
GN Name=CTAGE8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cTAGE family. {ECO:0000305}.
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DR EMBL; AC004889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS64791.1; -.
DR RefSeq; NP_001265436.1; NM_001278507.1.
DR AlphaFoldDB; P0CG41; -.
DR SMR; P0CG41; -.
DR BioGRID; 936688; 1.
DR IntAct; P0CG41; 1.
DR iPTMnet; P0CG41; -.
DR PhosphoSitePlus; P0CG41; -.
DR BioMuta; CTAGE8; -.
DR DMDM; 300680906; -.
DR jPOST; P0CG41; -.
DR MassIVE; P0CG41; -.
DR MaxQB; P0CG41; -.
DR PaxDb; P0CG41; -.
DR PeptideAtlas; P0CG41; -.
DR PRIDE; P0CG41; -.
DR Antibodypedia; 32719; 2 antibodies from 2 providers.
DR DNASU; 100142659; -.
DR Ensembl; ENST00000487179.2; ENSP00000417289.1; ENSG00000289604.1.
DR Ensembl; ENST00000672571.1; ENSP00000500005.1; ENSG00000288181.1.
DR Ensembl; ENST00000672823.1; ENSP00000500425.1; ENSG00000288181.1.
DR GeneID; 100142659; -.
DR KEGG; hsa:100142659; -.
DR MANE-Select; ENST00000487179.2; ENSP00000417289.1; NM_001278507.2; NP_001265436.1.
DR UCSC; uc010lpe.5; human.
DR CTD; 100142659; -.
DR GeneCards; CTAGE8; -.
DR HGNC; HGNC:37294; CTAGE8.
DR HPA; ENSG00000244693; Tissue enhanced (testis).
DR neXtProt; NX_P0CG41; -.
DR VEuPathDB; HostDB:ENSG00000244693; -.
DR eggNOG; ENOG502QUND; Eukaryota.
DR GeneTree; ENSGT00950000182767; -.
DR HOGENOM; CLU_002106_2_0_1; -.
DR InParanoid; P0CG41; -.
DR OMA; PYGFPWD; -.
DR OrthoDB; 104022at2759; -.
DR PhylomeDB; P0CG41; -.
DR TreeFam; TF333137; -.
DR PathwayCommons; P0CG41; -.
DR BioGRID-ORCS; 100142659; 53 hits in 179 CRISPR screens.
DR GenomeRNAi; 100142659; -.
DR Pharos; P0CG41; Tdark.
DR PRO; PR:P0CG41; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P0CG41; protein.
DR Bgee; ENSG00000244693; Expressed in mucosa of transverse colon and 83 other tissues.
DR Genevisible; P0CG41; HS.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0035459; P:vesicle cargo loading; IBA:GO_Central.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..777
FT /note="cTAGE family member 8"
FT /id="PRO_0000395454"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 510..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..269
FT /evidence="ECO:0000255"
FT COILED 339..498
FT /evidence="ECO:0000255"
FT COMPBIAS 524..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 88077 MW; CCB6B3DAFBF84D19 CRC64;
MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGQVSE
LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE
EKISRATEGL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ
TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP
VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE
MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP
FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF
