CTGE9_HUMAN
ID CTGE9_HUMAN Reviewed; 777 AA.
AC A4FU28;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=cTAGE family member 9;
DE Short=Protein cTAGE-9;
GN Name=CTAGE9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-763.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cTAGE family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC005587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101322; AAI01323.1; -; mRNA.
DR CCDS; CCDS47475.1; -.
DR RefSeq; NP_001139131.1; NM_001145659.1.
DR AlphaFoldDB; A4FU28; -.
DR SMR; A4FU28; -.
DR BioGRID; 569105; 1.
DR IntAct; A4FU28; 1.
DR MINT; A4FU28; -.
DR iPTMnet; A4FU28; -.
DR PhosphoSitePlus; A4FU28; -.
DR BioMuta; CTAGE9; -.
DR jPOST; A4FU28; -.
DR MassIVE; A4FU28; -.
DR MaxQB; A4FU28; -.
DR PaxDb; A4FU28; -.
DR PeptideAtlas; A4FU28; -.
DR PRIDE; A4FU28; -.
DR Antibodypedia; 72037; 1 antibodies from 1 providers.
DR DNASU; 643854; -.
DR Ensembl; ENST00000314099.10; ENSP00000395587.2; ENSG00000236761.6.
DR GeneID; 643854; -.
DR KEGG; hsa:643854; -.
DR MANE-Select; ENST00000314099.10; ENSP00000395587.2; NM_001145659.1; NP_001139131.1.
DR UCSC; uc011ece.3; human.
DR CTD; 643854; -.
DR GeneCards; CTAGE9; -.
DR HGNC; HGNC:37275; CTAGE9.
DR HPA; ENSG00000236761; Tissue enriched (testis).
DR neXtProt; NX_A4FU28; -.
DR PharmGKB; PA165617886; -.
DR VEuPathDB; HostDB:ENSG00000236761; -.
DR eggNOG; ENOG502QUND; Eukaryota.
DR GeneTree; ENSGT00950000182767; -.
DR HOGENOM; CLU_002106_2_0_1; -.
DR InParanoid; A4FU28; -.
DR OMA; HEKINHA; -.
DR OrthoDB; 104022at2759; -.
DR PhylomeDB; A4FU28; -.
DR TreeFam; TF333137; -.
DR PathwayCommons; A4FU28; -.
DR SignaLink; A4FU28; -.
DR BioGRID-ORCS; 643854; 210 hits in 984 CRISPR screens.
DR GenomeRNAi; 643854; -.
DR Pharos; A4FU28; Tdark.
DR PRO; PR:A4FU28; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; A4FU28; protein.
DR Bgee; ENSG00000236761; Expressed in right testis and 55 other tissues.
DR Genevisible; A4FU28; HS.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0035459; P:vesicle cargo loading; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..777
FT /note="cTAGE family member 9"
FT /id="PRO_0000395455"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 510..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..269
FT /evidence="ECO:0000255"
FT COILED 339..494
FT /evidence="ECO:0000255"
FT COMPBIAS 524..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 87953 MW; 7257F26827B7D432 CRC64;
MEEPGATPQP YLGLVLEELG RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
AAEEARSLEA TCEKLSRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGQVSE
LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELKVNSQ
WENGANLDDP PKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE
EKISHATEEL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
KENAHNKQKL TERELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ
TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP
VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE
MESSRNDAKD DLGNLNVPDS SLPAENEATG PGLIPPPLAP ISGPLFPVDT RGPFMRRGPP
FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF
