ID   CTHA2_CONVC             Reviewed;         144 AA.
AC   A0A0F7Z3J2;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2015, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Thyrostimulin alpha-2 subunit {ECO:0000303|PubMed:26301480};
DE   Flags: Precursor;
OS   Conus victoriae (Queen Victoria cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=319920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=24505301; DOI=10.1371/journal.pone.0087648;
RA   Robinson S.D., Safavi-Hemami H., McIntosh L.D., Purcell A.W., Norton R.S.,
RA   Papenfuss A.T.;
RT   "Diversity of conotoxin gene superfamilies in the venomous snail, Conus
RT   victoriae.";
RL   PLoS ONE 9:E87648-E87648(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 63-77 AND 104-126,
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=26301480; DOI=10.1016/j.ygcen.2015.07.012;
RA   Robinson S.D., Li Q., Bandyopadhyay P.K., Gajewiak J., Yandell M.,
RA   Papenfuss A.T., Purcell A.W., Norton R.S., Safavi-Hemami H.;
RT   "Hormone-like peptides in the venoms of marine cone snails.";
RL   Gen. Comp. Endocrinol. 244:11-18(2017).
CC   -!- SUBUNIT: Heterodimer with GPHB5; non-covalently-linked.
CC       {ECO:0000250|UniProtKB:Q96T91}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26301480}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:26301480}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC       {ECO:0000250|UniProtKB:Q96T91, ECO:0000305|PubMed:26301480}.
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DR   EMBL; GAIH01000105; JAI08984.1; -; mRNA.
DR   AlphaFoldDB; A0A0F7Z3J2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..41
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..144
FT                   /note="Thyrostimulin alpha-2 subunit"
FT                   /evidence="ECO:0000250|UniProtKB:Q96T91,
FT                   ECO:0000305|PubMed:26301480"
FT                   /id="PRO_0000439369"
FT   DISULFID        52..107
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        66..121
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        76..136
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        80..138
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
SQ   SEQUENCE   144 AA;  15734 MW;  AD849E339C6E6E71 CRC64;
     MGRRDSGRAV AQRYRGVTRG VTVIACLMVV CACVGLCDAT GQKRHSWEAP GCHLVGHTRV
     VRIPDCVPFQ ITTNACRGFC VSYAIPSPYQ TLVYNPNHII TSRAACCDII DTLDIPVQVT
     CVDGVREIVF KSARSCACSI CRRE