ID   CTHB1_CHICK             Reviewed;         251 AA.
AC   Q5F378; A7M6V2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Cathelicidin-B1;
DE            Short=CATH-B1;
DE   Flags: Precursor;
GN   Name=CATHB1; ORFNames=RCJMB04_29o22;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION,
RP   AND TISSUE SPECIFICITY.
RC   TISSUE=Bursa of Fabricius;
RX   PubMed=17827276; DOI=10.1073/pnas.0707037104;
RA   Goitsuka R., Chen C.-I.H., Benyon L., Asano Y., Kitamura D., Cooper M.D.;
RT   "Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell
RT   gateway.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:15063-15068(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Has potent antimicrobial activity against Gram-positive and
CC       Gram-negative bacteria (in vitro). May play a role in the innate immune
CC       response. {ECO:0000269|PubMed:17827276}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17827276}.
CC   -!- TISSUE SPECIFICITY: Detected in bursa of Fabricius, in filamentous
CC       structures surrounding the basal and lateral surfaces of bursal M cells
CC       (at protein level). Detected in bursa of Fabricius, in secretory
CC       enterocytes of the interfollicular bursal epithelium, but not in M
CC       cells. {ECO:0000269|PubMed:17827276}.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; AB307733; BAF75951.1; -; mRNA.
DR   EMBL; AB308318; BAF75953.1; -; Genomic_DNA.
DR   EMBL; AJ851772; CAH65406.1; -; mRNA.
DR   RefSeq; NP_001258101.1; NM_001271172.1.
DR   AlphaFoldDB; Q5F378; -.
DR   SMR; Q5F378; -.
DR   STRING; 9031.ENSGALP00000042265; -.
DR   TCDB; 1.C.33.1.8; the cathelicidin (cathelicidin) family.
DR   GeneID; 100858412; -.
DR   KEGG; gga:100858412; -.
DR   CTD; 100858412; -.
DR   VEuPathDB; HostDB:geneid_100858412; -.
DR   eggNOG; ENOG502TDFH; Eukaryota.
DR   InParanoid; Q5F378; -.
DR   OrthoDB; 1222707at2759; -.
DR   PRO; PR:Q5F378; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0099512; C:supramolecular fiber; IMP:AgBase.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:AgBase.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:AgBase.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..211
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333226"
FT   PEPTIDE         212..251
FT                   /note="Cathelicidin-B1"
FT                   /id="PRO_0000333227"
FT   REGION          29..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        172..181
FT                   /evidence="ECO:0000250"
FT   DISULFID        189..205
FT                   /evidence="ECO:0000250"
FT   CONFLICT        77
FT                   /note="A -> ASPGLDGST (in Ref. 1; BAF75953/BAF75951)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        135
FT                   /note="K -> R (in Ref. 1; BAF75953/BAF75951)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   251 AA;  26927 MW;  5C0B9B423E982776 CRC64;
     MGRMWASEVL LLLLLGSSRA VTPGLDVSTA PGLDGSIPPG LDGSVSPGLD GSVSPGLDGS
     ASPGLDGSVS PGLDGSASPG LDGSTPAGRD GTITPKLEGT ITPKQDGSIS PSWPWRWPIT
     YLDAILAAVR LLNQKISGPC ILRLREAQPR PGWVGTLQRR REVSFLVEDG PCPPGVDCRS
     CEPGALQHCV GTVSIEQQPT AELRCRPLRP QPIRNWWIRI WEWLNGIRKR LRQRSPFYVR
     GHLNVTSTPQ P