ID   CTHB5_CONVC             Reviewed;         135 AA.
AC   A0A0F7YZI5;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2015, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Thyrostimulin beta-5 subunit {ECO:0000303|PubMed:26301480};
DE   Flags: Precursor;
OS   Conus victoriae (Queen Victoria cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=319920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=24505301; DOI=10.1371/journal.pone.0087648;
RA   Robinson S.D., Safavi-Hemami H., McIntosh L.D., Purcell A.W., Norton R.S.,
RA   Papenfuss A.T.;
RT   "Diversity of conotoxin gene superfamilies in the venomous snail, Conus
RT   victoriae.";
RL   PLoS ONE 9:E87648-E87648(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=26301480; DOI=10.1016/j.ygcen.2015.07.012;
RA   Robinson S.D., Li Q., Bandyopadhyay P.K., Gajewiak J., Yandell M.,
RA   Papenfuss A.T., Purcell A.W., Norton R.S., Safavi-Hemami H.;
RT   "Hormone-like peptides in the venoms of marine cone snails.";
RL   Gen. Comp. Endocrinol. 244:11-18(2017).
CC   -!- SUBUNIT: Heterodimer with GPHA2; non-covalently-linked.
CC       {ECO:0000250|UniProtKB:Q86YW7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q86YW7}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:26301480}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000250|UniProtKB:Q96T91, ECO:0000305|PubMed:26301480}.
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DR   EMBL; GAIH01000106; JAI08983.1; -; mRNA.
DR   AlphaFoldDB; A0A0F7YZI5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..135
FT                   /note="Thyrostimulin beta-5 subunit"
FT                   /evidence="ECO:0000250|UniProtKB:Q86YW7"
FT                   /id="PRO_5002525607"
FT   DISULFID        30..87
FT                   /evidence="ECO:0000255"
FT   DISULFID        54..102
FT                   /evidence="ECO:0000255"
FT   DISULFID        63..118
FT                   /evidence="ECO:0000255"
FT   DISULFID        67..120
FT                   /evidence="ECO:0000255"
FT   DISULFID        123..130
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   135 AA;  14802 MW;  5C9BB5B947C002D4 CRC64;
     MVMPLVLSLA LTPPPLCHAT LVDPRTTLQC HVRSYTFRAT KPPIVNENGD PVTCQGDVRV
     SSCWGRCDSS EIGDYKMPFK ISNHPVCTYT GRVSRTVRLS QCAGYPDPTV QVFDATGCAC
     QFCNSETQLC EKLNG