ID   CTHL1_SHEEP             Reviewed;         155 AA.
AC   P54230;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Cathelicidin-1;
DE   AltName: Full=Bactenecin-1;
DE            Short=Bac1;
DE   AltName: Full=Cyclic dodecapeptide;
DE   Flags: Precursor;
GN   Name=CATHL1A; Synonyms=BAC1A, DODEA;
GN   and
GN   Name=CATHL1B; Synonyms=BAC1B, DODEB;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7498547; DOI=10.1016/0014-5793(95)01285-3;
RA   Bagella L., Scocchi M., Zanetti M.;
RT   "cDNA sequences of three sheep myeloid cathelicidins.";
RL   FEBS Lett. 376:225-228(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=9461419; DOI=10.1016/s0378-1119(97)00569-6;
RA   Huttner K.M., Lambeth M.R., Burkin H.R., Broad T.E.;
RT   "Localization and genomic organization of sheep antimicrobial peptides
RT   genes.";
RL   Gene 206:85-91(1998).
CC   -!- FUNCTION: Potent microbicidal activity; active against S.aureus and
CC       E.coli. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; L46853; AAA85469.1; -; mRNA.
DR   EMBL; U60595; AAB49710.1; -; Genomic_DNA.
DR   EMBL; U60596; AAB49711.1; -; Genomic_DNA.
DR   PIR; S68229; S68229.
DR   RefSeq; NP_001009772.1; NM_001009772.1.
DR   AlphaFoldDB; P54230; -.
DR   SMR; P54230; -.
DR   STRING; 9940.ENSOARP00000001457; -.
DR   Ensembl; ENSOART00020038623; ENSOARP00020031992; ENSOARG00020024644.
DR   Ensembl; ENSOART00020038667; ENSOARP00020032031; ENSOARG00020024674.
DR   GeneID; 443312; -.
DR   KEGG; oas:443312; -.
DR   CTD; 443312; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   OrthoDB; 1534863at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..143
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004698"
FT   PEPTIDE         144..155
FT                   /note="Cathelicidin-1"
FT                   /id="PRO_0000004699"
FT   MOD_RES         30
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P22226"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        146..154
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   155 AA;  17648 MW;  1690638C791B1736 CRC64;
     METQRASLSL GRCSLWLLLL GLALPSASAQ VLSYREAVLR AVDQLNEQSS EPNIYRLLEL
     DQPPQDDEDP DSPKRVSFRV KETVCPRTTQ QPPEQCDFKE NGLLKRCEGT VTLDQVRGNF
     DITCNNHQSI RITKQPWAPP QAARICRIIF LRVCR