ID   CTHL2_CAPHI             Reviewed;         176 AA.
AC   P82018; Q4JFB9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Cathelicidin-2;
DE   AltName: Full=Bactenecin-5;
DE            Short=Bac5;
DE   AltName: Full=ChBac5;
DE   Flags: Precursor;
GN   Name=CATHL2; Synonyms=BAC5;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RA   Zhao C.;
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 131-149 AND 151-153, AND FUNCTION.
RC   TISSUE=Bone marrow, and Leukocyte;
RX   PubMed=10417180; DOI=10.1128/iai.67.8.4106-4111.1999;
RA   Shamova O., Brogden K.A., Zhao C., Nguyen T., Kokryakov V.N., Lehrer R.I.;
RT   "Purification and properties of proline-rich antimicrobial peptides from
RT   sheep and goat leukocytes.";
RL   Infect. Immun. 67:4106-4111(1999).
CC   -!- FUNCTION: Binds to the lipid A moiety of bacterial lipopolysaccharides
CC       (LPS), a glycolipid present in the outer membrane of all Gram-negative
CC       bacteria. Shows a potent antimicrobial activity against the Gram-
CC       negative bacteria E.coli, S.typhimurium and P.aeruginosa. Less active
CC       against the Gram-positive bacteria S.aureus, L.monocytogenes and
CC       B.subtilis. {ECO:0000269|PubMed:10417180}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: BAC5 sequence consists almost exclusively of X-P-P-Y repeats.
CC   -!- PTM: Elastase is responsible for its maturation.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; Y18873; CAC80206.1; -; mRNA.
DR   RefSeq; NP_001272506.1; NM_001285577.1.
DR   AlphaFoldDB; P82018; -.
DR   SMR; P82018; -.
DR   STRING; 9925.ENSCHIP00000028231; -.
DR   Ensembl; ENSCHIT00000036100; ENSCHIP00000028231; ENSCHIG00000023827.
DR   GeneID; 100861213; -.
DR   KEGG; chx:100861213; -.
DR   CTD; 100861213; -.
DR   GeneTree; ENSGT00390000000410; -.
DR   OMA; PNDEVDP; -.
DR   OrthoDB; 1534863at2759; -.
DR   Proteomes; UP000291000; Chromosome 22.
DR   Bgee; ENSCHIG00000023827; Expressed in spleen and 12 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..130
FT                   /evidence="ECO:0000269|PubMed:10417180"
FT                   /id="PRO_0000004703"
FT   PEPTIDE         131..173
FT                   /note="Cathelicidin-2"
FT                   /id="PRO_0000004704"
FT   PROPEP          174..176
FT                   /note="Removed in mature form"
FT                   /id="PRO_0000004705"
FT   REGION          135..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..176
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         30
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P19660"
FT   MOD_RES         173
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250|UniProtKB:P19660"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   176 AA;  19846 MW;  6FD7056C954E340A CRC64;
     METQGASLSL GRWSLWLLLL GLVVPLASAQ ALSYREAVLR AVGQLNERSS EANLYRLLEL
     DPAPNDEVDP GTRKPVSFTV KETVCPRTTQ QPPEECDFKE NGLVKQCVGT VTLDPSNDQF
     DINCNELQSV RFRPPIRRPP IRPPFNPPFR PPVRPPFRPP FRPPFRPPIG PFPGRR