ID   CTHL3_CAPHI             Reviewed;          26 AA.
AC   P85170;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Cathelicidin-3.4;
DE   AltName: Full=Bactenecin-3.4;
DE            Short=Bac3.4;
DE   AltName: Full=ChBac3.4;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND
RP   AMIDATION AT LEU-26.
RC   TISSUE=Leukocyte;
RA   Shamova O., Orlov D., Stegemann C., Lehrer R.I., Brogden K.A., Kolodkin N.,
RA   Hoffmann R., Kokryakov V.N.;
RL   Submitted (MAY-2007) to UniProtKB.
CC   -!- FUNCTION: Has potent antibacterial activity against the Gram-negative
CC       bacteria E.coli and P.aeruginosa. Less active against the Gram-positive
CC       bacteria S.aureus and L.monocytogenes. Has low hemolytic activity
CC       towards human red blood cells. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P19660}.
CC   -!- TISSUE SPECIFICITY: Leukocytes. {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=3376; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000255}.
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DR   AlphaFoldDB; P85170; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing;
KW   Hemolysis; Reference proteome; Secreted.
FT   PEPTIDE         1..26
FT                   /note="Cathelicidin-3.4"
FT                   /id="PRO_0000341516"
FT   MOD_RES         26
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   26 AA;  3377 MW;  C00381860D6929B9 CRC64;
     RFRLPFRRPP IRIHPPPFYP PFRRFL