ID   CTHL3_SHEEP             Reviewed;         190 AA.
AC   P50415;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Cathelicidin-3;
DE   AltName: Full=Bactenecin-7;
DE            Short=Bac7;
DE   AltName: Full=PR-59;
DE   Flags: Precursor;
GN   Name=CATHL3; Synonyms=BAC7, BAC7.5;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7498547; DOI=10.1016/0014-5793(95)01285-3;
RA   Bagella L., Scocchi M., Zanetti M.;
RT   "cDNA sequences of three sheep myeloid cathelicidins.";
RL   FEBS Lett. 376:225-228(1995).
CC   -!- FUNCTION: Exerts, in vitro, a potent antimicrobial activity. Probably
CC       due to an impairment of the function of the respiratory chain and of
CC       energy-dependent activities in the inner membrane of susceptible
CC       microorganisms (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; L46852; AAA85468.1; -; mRNA.
DR   PIR; S68230; S68230.
DR   RefSeq; NP_001009301.1; NM_001009301.1.
DR   PDB; 4JWE; X-ray; 1.95 A; C/D=131-151.
DR   PDB; 4JWI; X-ray; 1.90 A; C/D=165-173.
DR   PDBsum; 4JWE; -.
DR   PDBsum; 4JWI; -.
DR   AlphaFoldDB; P50415; -.
DR   SMR; P50415; -.
DR   STRING; 9940.ENSOARP00000001893; -.
DR   GeneID; 443311; -.
DR   KEGG; oas:443311; -.
DR   CTD; 281037; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   OrthoDB; 1534863at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Disulfide bond;
KW   Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..130
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004712"
FT   PEPTIDE         131..190
FT                   /note="Cathelicidin-3"
FT                   /id="PRO_0000004713"
FT   REGION          133..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..151
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..190
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         30
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P19661"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..124
FT                   /evidence="ECO:0000250"
FT   STRAND          168..170
FT                   /evidence="ECO:0007829|PDB:4JWI"
SQ   SEQUENCE   190 AA;  21829 MW;  E4AAFB1600E98371 CRC64;
     METQMASPSL GRCSLWLLLL GLLLPSASAQ ALSYREAVLR AVGQLNEKSS EVNLYRLLEL
     DPPPKDAEDQ GARKPVSFRV KETVCPRMSQ QPPEQCDFKE NGLVKQCVGT VSLDTSNDEF
     DLNCNELQSV RRLRPRRPRL PRPRPRPRPR PRSLPLPRPQ PRRIPRPILL PWRPPRPIPR
     PQPQPIPRWL