CTHL5_BOVIN
ID CTHL5_BOVIN Reviewed; 159 AA.
AC P54229; A5PJ96; B9UKL6;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Cathelicidin-5;
DE AltName: Full=Antibacterial peptide BMAP-28;
DE AltName: Full=Myeloid antibacterial peptide 28;
DE Flags: Precursor;
GN Name=CATHL5; Synonyms=BMAP28;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Bone marrow;
RX PubMed=8910461; DOI=10.1074/jbc.271.45.28375;
RA Skerlavaj B., Gennaro R., Bagella L., Merluzzi L., Risso A., Zanetti M.;
RT "Biological characterization of two novel cathelicidin-derived peptides and
RT identification of structural requirements for their antimicrobial and cell
RT lytic activities.";
RL J. Biol. Chem. 271:28375-28381(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate 44, Isolate 74, and Isolate JEW38;
RX PubMed=19136450; DOI=10.1093/jhered/esn112;
RA Gillenwaters E.N., Seabury C.M., Elliott J.S., Womack J.E.;
RT "Sequence analysis and polymorphism discovery in 4 members of the bovine
RT cathelicidin gene family.";
RL J. Hered. 100:241-245(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP CHARACTERIZATION.
RX PubMed=8706679; DOI=10.1111/j.1432-1033.1996.0769w.x;
RA Storici P., Tossi A., Lenarcic B., Romeo D.;
RT "Purification and structural characterization of bovine cathelicidins,
RT precursors of antimicrobial peptides.";
RL Eur. J. Biochem. 238:769-776(1996).
CC -!- FUNCTION: Exerts a potent antimicrobial activity against Gram-negative
CC and Gram-positive bacteria, including methicillin-resistant
CC Staphylococcus aureus, and fungi. {ECO:0000269|PubMed:8706679}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8706679}.
CC -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR EMBL; X97609; CAA66208.1; -; mRNA.
DR EMBL; EU751296; ACI31918.1; -; Genomic_DNA.
DR EMBL; EU751297; ACI31919.1; -; Genomic_DNA.
DR EMBL; EU751302; ACI31924.1; -; Genomic_DNA.
DR EMBL; BC142015; AAI42016.1; -; mRNA.
DR RefSeq; NP_776935.1; NM_174510.3.
DR PDB; 2NDC; NMR; -; A=132-149.
DR PDB; 2NDE; NMR; -; A=132-149.
DR PDBsum; 2NDC; -.
DR PDBsum; 2NDE; -.
DR AlphaFoldDB; P54229; -.
DR SMR; P54229; -.
DR STRING; 9913.ENSBTAP00000017763; -.
DR PaxDb; P54229; -.
DR PeptideAtlas; P54229; -.
DR PRIDE; P54229; -.
DR GeneID; 282167; -.
DR KEGG; bta:282167; -.
DR CTD; 282167; -.
DR eggNOG; ENOG502SAES; Eukaryota.
DR HOGENOM; CLU_121724_1_1_1; -.
DR InParanoid; P54229; -.
DR OrthoDB; 1534863at2759; -.
DR TreeFam; TF338457; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR001894; Cathelicidin-like.
DR InterPro; IPR018216; Cathelicidin_CS.
DR InterPro; IPR046350; Cystatin_sf.
DR PANTHER; PTHR10206; PTHR10206; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
DR PROSITE; PS00946; CATHELICIDINS_1; 1.
DR PROSITE; PS00947; CATHELICIDINS_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic; Antimicrobial; Disulfide bond;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..131
FT /id="PRO_0000004716"
FT PEPTIDE 132..159
FT /note="Cathelicidin-5"
FT /id="PRO_0000004717"
FT MOD_RES 30
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P19660"
FT DISULFID 86..97
FT /evidence="ECO:0000250"
FT DISULFID 108..125
FT /evidence="ECO:0000250"
FT TURN 134..136
FT /evidence="ECO:0007829|PDB:2NDC"
FT HELIX 137..143
FT /evidence="ECO:0007829|PDB:2NDC"
FT TURN 146..148
FT /evidence="ECO:0007829|PDB:2NDE"
SQ SEQUENCE 159 AA; 17616 MW; 89B7CB46C5EEC367 CRC64;
METQRASLSL GRWSLWLLLL GLALPSASAQ ALSYREAVLR AVDQLNEKSS EANLYRLLEL
DPPPKEDDEN PNIPKPVSFR VKETVCPRTS QQSPEQCDFK ENGLLKECVG TVTLDQVGSN
FDITCAVPQS VGGLRSLGRK ILRAWKKYGP IIVPIIRIG
