ID   CTHL6_BOVIN             Reviewed;         158 AA.
AC   P54228; B9UKM5;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Cathelicidin-6;
DE   AltName: Full=Antibacterial peptide BMAP-27;
DE   AltName: Full=Myeloid antibacterial peptide 27;
DE   Flags: Precursor;
GN   Name=CATHL6; Synonyms=BMAP27;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8910461; DOI=10.1074/jbc.271.45.28375;
RA   Skerlavaj B., Gennaro R., Bagella L., Merluzzi L., Risso A., Zanetti M.;
RT   "Biological characterization of two novel cathelicidin-derived peptides and
RT   identification of structural requirements for their antimicrobial and cell
RT   lytic activities.";
RL   J. Biol. Chem. 271:28375-28381(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 44, Isolate 74, and Isolate JEW38;
RX   PubMed=19136450; DOI=10.1093/jhered/esn112;
RA   Gillenwaters E.N., Seabury C.M., Elliott J.S., Womack J.E.;
RT   "Sequence analysis and polymorphism discovery in 4 members of the bovine
RT   cathelicidin gene family.";
RL   J. Hered. 100:241-245(2009).
CC   -!- FUNCTION: Exerts a potent antimicrobial activity against Gram-negative
CC       and Gram-positive bacteria, including methicillin-resistant
CC       Staphylococcus aureus, and fungi.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; X97608; CAA66207.1; -; mRNA.
DR   EMBL; EU751305; ACI31927.1; -; Genomic_DNA.
DR   EMBL; EU751306; ACI31928.1; -; Genomic_DNA.
DR   EMBL; EU751311; ACI31933.1; -; Genomic_DNA.
DR   RefSeq; NP_777257.1; NM_174832.3.
DR   PDB; 2KET; NMR; -; A=132-157.
DR   PDBsum; 2KET; -.
DR   AlphaFoldDB; P54228; -.
DR   SMR; P54228; -.
DR   STRING; 9913.ENSBTAP00000042250; -.
DR   TCDB; 1.C.33.1.11; the cathelicidin (cathelicidin) family.
DR   PaxDb; P54228; -.
DR   PeptideAtlas; P54228; -.
DR   PRIDE; P54228; -.
DR   Ensembl; ENSBTAT00000083146; ENSBTAP00000056939; ENSBTAG00000049629.
DR   GeneID; 317651; -.
DR   KEGG; bta:317651; -.
DR   CTD; 317651; -.
DR   VEuPathDB; HostDB:ENSBTAG00000049629; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   GeneTree; ENSGT00390000000410; -.
DR   HOGENOM; CLU_121724_1_1_1; -.
DR   InParanoid; P54228; -.
DR   OMA; CPRIMKQ; -.
DR   OrthoDB; 1534863at2759; -.
DR   TreeFam; TF338457; -.
DR   EvolutionaryTrace; P54228; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000049629; Expressed in thymus and 17 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Disulfide bond; Fungicide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..131
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004714"
FT   PEPTIDE         132..158
FT                   /note="Cathelicidin-6"
FT                   /id="PRO_0000004715"
FT   DISULFID        86..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..125
FT                   /evidence="ECO:0000250"
FT   HELIX           134..148
FT                   /evidence="ECO:0007829|PDB:2KET"
FT   HELIX           153..156
FT                   /evidence="ECO:0007829|PDB:2KET"
SQ   SEQUENCE   158 AA;  17852 MW;  DD54B613BEFE4BD2 CRC64;
     METQRASLSL GRWSLWLLLL GLALPSASAQ ALSYREAVLR AVDQFNERSS EANLYRLLEL
     DPPPKEDDEN PNIPKPVSFR VKETVCPRTS QQPAEQCDFK ENGLVKQCVG TVTLDAVKGK
     INVTCEELQS VGRFKRFRKK FKKLFKKLSP VIPLLHLG